Emerg Infect Dis. Influenza A (H5N1) Viruses from Pigs, Indonesia

[Giuseppe]

Influenza A (H5N1) Viruses from Pigs, Indonesia (Emerg Infect Dis., abstract, edited)

[Source: Emerging Infectious Diseases Journal, full PDF Document (LINK). Abstract, edited.]

DOI: 10.3201/eid1610.100508
Suggested citation for this article: Nidom CA, Takano R, Yamada S, Sakai-Tagawa Y, Daulay S, Aswadi, D, et al. Influenza A (H5N1) viruses from pigs, Indonesia. Emerg Infect Dis. 2010 Oct; [Epub ahead of print]

Influenza A (H5N1) Viruses from Pigs, Indonesia

Chairul A. Nidom, Ryo Takano, Shinya Yamada, Yuko Sakai-Tagawa, Syafril Daulay, Didi Aswadi, Takashi Suzuki, Yasuo Suzuki, Kyoko Shinya, Kiyoko Iwatsuki-Horimoto, Yukiko Muramoto, and Yoshihiro Kawaoka

Author affiliations: Airlangga University, Surabaya, East Java, Indonesia (C.A. Nidom); University of Tokyo, Tokyo, Japan (R. Takano, S. Yamada, Y. Sakai-Tagawa, K. Iwatsuki-Horimoto, Y. Muramoto, Y. Kawaoka); Ministry of Agriculture, Jakarta, Indonesia (S. Daulay); Agriculture and Livestock Agency, Tangerang, Indonesia (D. Aswadi); University of Shizuoka, Shizuoka City, Japan (T. Suzuki, Y. Suzuki); Chubu University, Kasugai City, Japan (Y. Suzuki); Kobe University, Kobe, Japan (K. Shinya, Y. Kawaoka); and University of Wisconsin, Madison, Wisconsin, USA (Y. Kawaoka)


Pigs have long been considered potential intermediate hosts in which avian influenza viruses can adapt to humans. To determine whether this potential exists for pigs in Indonesia, we conducted surveillance during 2005?2009. We found that 52 pigs in 4 provinces were infected during 2005?2007 but not 2008?2009. Phylogenetic analysis showed that the viruses had been introduced into the pig population in Indonesia on at least 3 occasions. One isolate had acquired the ability to recognize a human-type receptor. No infected pig had influenza-like symptoms, indicating that influenza A (H5N1) viruses can replicate undetected for prolonged periods, facilitating avian virus adaptation to mammalian hosts. Our data suggest that pigs are at risk for infection during outbreaks of influenza virus A (H5N1) and can serve as intermediate hosts in which this avian virus can adapt to mammals.

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[Gert van der Hoek]

Re: Emerg Infect Dis. Influenza A (H5N1) Viruses from Pigs, Indonesia

A snip from the study, reported in the previous post:


In summary,

we found that influenza A (H5N1) viruses have been transmitted multiple times to pig populations in Indonesia and that 1 virus has acquired the ability to recognize human-type receptors.

Of particular concern is that pigs infected with influenza A (H5N1) viruses showed no significant influenza-like signs and were likely transported to and from different provinces in Indonesia.

On the basis of our findings, we encourage the Indonesian government to control the transport of pigs within Indonesia.

Otherwise, opportunities for this avian virus to adapt to mammals will increase, as will the risk for emergence of a new pandemic influenza virus.

Edit; also see this study: http://www.flutrackers.com/forum/sho...937#post366937

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[sharon sanders]

Re: Emerg Infect Dis. Influenza A (H5N1) Viruses from Pigs, Indonesia

Indonesia has a higher proportion of domestic pigs infected with avian influenza virus
Sept. 2, 2010 08:25:03 Source: Xinhuanet Editor: YANG Jing 【font size】 【Message】 【Print】 【Close】

Xinhua Tokyo on Sept. 1 (Xinhua blue construction), Japanese researchers recently reported that their home pigs in Indonesia detected the H5N1 strain of bird flu virus in pigs infected with the virus accounted for the total sample of 7.4 %. The researchers warned that in future the need to closely monitor changes in the virus at home and pigs.

Medical Research Institute of Tokyo University Professor Yoshihiro Kawaoka of the research team, led by the United States in the recently published "Emerging Infectious Diseases," published in the journal paper that by the year 2005 to 2009, from 23 pig farms in different parts of Indonesia and meat processing plants of 702 domestic pigs in vivo nasal fluid and blood were collected through tests, in which the body was found in 52 pigs, H5N1 avian influenza virus. These viruses are 2005 to 2007 detected, in the period from 2008 to 2009 were not detected the virus, but part of the pig in vivo detection of the H5N1 strain of bird flu virus for the antibodies, these pigs should have infected with the virus.

Pig farms in the vicinity of the virus found in flocks has been H5N1 strain of bird flu pandemic, the virus in pigs and chickens in the pandemic virus is similar to it that the virus is transmitted from chicken to pork.

As the pigs will also infected with the virus spread in birds and human transmission of the virus, the avian virus in pigs may be susceptible to human nature. Researchers believe that, H5N1 avian influenza virus in pigs, if changes were interpersonal communication ability, it may threaten human health.

http://news.xinhuanet.com/health/2010-09/02/c_12509417.htm

[Gert van der Hoek]

Re: Emerg Infect Dis. Influenza A (H5N1) Viruses from Pigs, Indonesia

Excerpt from a speech of Kawaoka on a seminar - machinetranslated

2010. 12.17



A/H5N1 virus isolation from pigs in Indonesia, "meaning"

Flu ( A/H1N1Pdm ) has occurred, has a feeling of faded out of the shadow of bird flu A/H5N1 .

However, the risk of adaption to humans, rather seems to be growing.

Institute of Medical Science Professor Hiroshi Yoshi Kawaoka says (photo), according to research group, led by the most obvious cases of A/H5N1 avian influenza infection in humans in Indonesia , from the swine A/H5N1 virus was found. In addition, one isolate had acquired the ability to recognize human-type receptors.

　The findings of Airlangga University and his colleagues have Chairul A. Nidom Indonesian National Emerging Infectious Diseases (Vol.16, No.10, 10,2010) announced.

　Nidom their group said, "can be an intermediate host of pigs adapt to humans when the bird flu virus" that has been pointed out, avian influenza A/H5N1 thirds of the world's cases of human infection one in Indonesia has reached, and tried to detect isolates from pigs.

　
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That unless efforts to prevent the development of the human form of adaptation, increasing the risk of pandemic influenza virus emergence of new risks will only increase.

http://medical.nikkeibp.co.jp/leaf/all/special/pandemic/topics/201012/517854.html