Arch Virol . Growth capability of epidemic influenza viruses in Japan since the 2009 H1N1 pandemic

[tetano]

Arch Virol


. 2021 Feb 12.
doi: 10.1007/s00705-021-04976-5. Online ahead of print.
Growth capability of epidemic influenza viruses in Japan since the 2009 H1N1 pandemic


Akeno Tsuneki-Tokunaga ^{1 2} , Kyosuke Kanai ^{1 2} , Asao Itagaki ^{1 2} , Hideaki Tsuchie ^{2 3} , Takayoshi Okada ^{2 4} , Masaaki Kasagi ^{2 5} , Kiyoshi Tanaka ^{2 6} , Miho Aoki ¹ , Alfredo Jr A Hinay ¹ , Seiji Kageyama ^{7 8}



Affiliations

• PMID: 33580378
• DOI: 10.1007/s00705-021-04976-5

Abstract

The correlation of viral growth capability (n = 156) with the viral load in nasopharyngeal swabs (n = 76) was assessed. Epidemic influenza A/H1N1, A/H3N2, and B viruses showed a wide range of growth capability (10⁴-10¹¹ copies/mL) in Madin-Darby canine kidney cells. The growth was correlated with the nasopharyngeal viral load (r = 0.53). Six selected strains showed growth-dependent cell death (r = 0.96) in a growth kinetics assay. Epidemic influenza viruses exhibit a wide range of growth capability. Growth capability should be considered one of the key factors in disease prognosis.