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Emerg Infect Dis. Cross-Reactive Antibodies to Pandemic (H1N1) 2009 Virus, Singapore
Cross-Reactive Antibodies to Pandemic (H1N1) 2009 Virus, Singapore (Emerg Infect Dis., extract, edited)
[Source: Emerging Infectious Diseases Review, Full PDF Document (LINK). Excerpt, edited.]
DOI: 10.3201/eid1605.091678
Suggested citation for this article: Tang JW, Tambyah PA, Wilder-Smith A, Puong K-Y, Shaw R, Barr IG, et al. Cross-reactive antibodies to pandemic (H1N1) 2009 virus, Singapore [letter]. Emerg Infect Dis. 2010 May; [Epub ahead of print]
Cross-Reactive Antibodies to Pandemic (H1N1) 2009 Virus, Singapore
To the Editor:
Accumulating evidence suggests that the degree of serologic cross-reactivity to pandemic (H1N1) 2009 virus varies between populations worldwide. To assess potential serologic cross-reactivity in Singapore, we obtained serum samples during May?June 2009 from 50 randomly recruited, healthy volunteers born mostly before 1958 (i.e., potentially those with some natural exposure to the then circulating H1N1/1918-like subtype viruses) before widespread transmission of pandemic (H1N1) 2009 virus in Singapore. Standard serologic hemagglutination-inhibition (HI) tests (1) were performed in 2 reference laboratories (Singapore during July?October 2009 and Melbourne, Australia, in January 2010), and microneutralization (MN) tests (2) were performed in 1 reference laboratory (Singapore) for each serum sample against pandemic (H1N1) 2009 virus (A/Auckland/1/2009) and seasonal influenza (H1N1) virus (A/Brisbane/59/2007). The study was reviewed and approved by the National Healthcare Group Domain-Specific Review Board (ref no. E/09/289, J.W.T. principal investigator).
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[Source: Emerging Infectious Diseases Review, Full PDF Document (LINK). Excerpt, edited.]
DOI: 10.3201/eid1605.091678
Suggested citation for this article: Tang JW, Tambyah PA, Wilder-Smith A, Puong K-Y, Shaw R, Barr IG, et al. Cross-reactive antibodies to pandemic (H1N1) 2009 virus, Singapore [letter]. Emerg Infect Dis. 2010 May; [Epub ahead of print]
Cross-Reactive Antibodies to Pandemic (H1N1) 2009 Virus, Singapore
To the Editor:
Accumulating evidence suggests that the degree of serologic cross-reactivity to pandemic (H1N1) 2009 virus varies between populations worldwide. To assess potential serologic cross-reactivity in Singapore, we obtained serum samples during May?June 2009 from 50 randomly recruited, healthy volunteers born mostly before 1958 (i.e., potentially those with some natural exposure to the then circulating H1N1/1918-like subtype viruses) before widespread transmission of pandemic (H1N1) 2009 virus in Singapore. Standard serologic hemagglutination-inhibition (HI) tests (1) were performed in 2 reference laboratories (Singapore during July?October 2009 and Melbourne, Australia, in January 2010), and microneutralization (MN) tests (2) were performed in 1 reference laboratory (Singapore) for each serum sample against pandemic (H1N1) 2009 virus (A/Auckland/1/2009) and seasonal influenza (H1N1) virus (A/Brisbane/59/2007). The study was reviewed and approved by the National Healthcare Group Domain-Specific Review Board (ref no. E/09/289, J.W.T. principal investigator).
(...)
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