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Proc Natl Acad Sci USA. Evolution in health and medicine Sackler colloquium: a public choice framework for controlling transmissible and evolving diseases.

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  • Proc Natl Acad Sci USA. Evolution in health and medicine Sackler colloquium: a public choice framework for controlling transmissible and evolving diseases.

    Evolution in health and medicine Sackler colloquium: a public choice framework for controlling transmissible and evolving diseases. (Proc Natl Acad Sci USA, abstract, edited)
    [Source: US National Library of Medicine, LINK. EDITED.]

    Proc Natl Acad Sci U S A. 2010 Jan 26;107 Suppl 1:1696-701. Epub 2009 Dec 14.

    Evolution in health and medicine Sackler colloquium: a public choice framework for controlling transmissible and evolving diseases.

    Althouse BM, Bergstrom TC, Bergstrom CT. - Department of Biology, University of Washington, Seattle, WA 98195-1800, USA.


    Control measures used to limit the spread of infectious disease often generate externalities. Vaccination for transmissible diseases can reduce the incidence of disease even among the unvaccinated, whereas antimicrobial chemotherapy can lead to the evolution of antimicrobial resistance and thereby limit its own effectiveness over time. We integrate the economic theory of public choice with mathematical models of infectious disease to provide a quantitative framework for making allocation decisions in the presence of these externalities. To illustrate, we present a series of examples: vaccination for tetanus, vaccination for measles, antibiotic treatment of otitis media, and antiviral treatment of pandemic influenza.

    PMID: 20018681 [PubMed - indexed for MEDLINE]
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