State-level estimates of excess hospitalizations and deaths associated with influenza

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Influenza Other Respir Viruses. 2019 Nov 7. doi: 10.1111/irv.12700. [Epub ahead of print] State-level estimates of excess hospitalizations and deaths associated with influenza.

Czaja CA^1,2,3, Miller L², Colborn K², Cockburn MG², Alden N¹, Herlihy RK¹, Sim?es EAF^2,3.
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1 Colorado Department of Public Health and Environment, Denver, CO, USA. 2 Colorado School of Public Health, Aurora, CO, USA. 3 University of Colorado School of Medicine, Aurora, CO, USA.

Abstract

BACKGROUND:

National estimates of influenza burden may not reflect state-level influenza activity, and local surveillance may not capture the full burden of influenza.
METHODS:

To provide state-level information about influenza burden, we estimated excess pneumonia and influenza (P&I) and respiratory and circulatory (R&C) hospitalizations and deaths in Colorado from local hospital discharge records, death certificates, and influenza virus surveillance using negative binomial models.
RESULTS:

From July 2007 to June 2016, influenza was associated with an excess of 17 911 P&I hospitalizations (95%CI: 15 227, 20 354), 30 811 R&C hospitalizations (95%CI: 24 344, 37 176), 1,064 P&I deaths (95%CI: 757, 1298), and 3828 R&C deaths (95%CI: 2060, 5433). There was a large burden of influenza A(H1N1) among persons aged 0-64 years, with high median seasonal rates of excess hospitalization among persons aged 0-4 years. Persons aged ≥65 years experienced the largest numbers and highest median seasonal rates of excess hospitalization and death associated with influenza A (H3N2). The burden of influenza B was generally lower, with elevated median seasonal rates of excess hospitalization among persons aged 0-4 years and ≥65 years.
CONCLUSIONS:

These findings complement existing influenza surveillance. Periodic state-level estimates of influenza disease burden may be useful for setting state public health priorities and planning prevention and control initiatives.
? 2019 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.


KEYWORDS:

death; hospitalization; human; influenza; public health

PMID: 31702114 DOI: 10.1111/irv.12700
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