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J Med Virol. 2019 Jun 23. doi: 10.1002/jmv.25524. [Epub ahead of print]
High incidence of rhinovirus infection in children with community acquired pneumonia from a city in the Brazilian pre-Amazon region.
Dos Santos Ferreira HL1, Costa KLP1, Cariolano MS1, Oliveira GS1, Felipe KKP1, Silva ESA1, Alves MS1, Maramaldo CEC1, de Sousa EM1, Rego JS2, Silva ICPA1, Albuquerque RKS3, Ara?jo NSC3, Amorim AMM3, Costa LD3, Pinheiro CS3, Guimar?es VA4, Santos MC5, Mello WA5, Falcai A6, Lima-Neto LG1.
Author information
Abstract
Community-acquired pneumonia (CAP) is the leading cause of child death worldwide. Viruses are the most common pathogens associated with CAP in children, but their incidence varies greatly. This study investigated the presence of respiratory syncytial virus (RSV), adenovirus, human rhinovirus (HRV), human metapneumovirus (HMPV), human coronavirus (HCoV-OC43 and HCoV-NL63), and influenza A virus (FluA) in children with CAP and the contributing risk factors. Here, children with acute respiratory infections were screened by pediatrics; and a total of 150 radiographically-confirmed CAP patients (aged 3 months to 10 years) from two clinical centers in Sao Luis, Brazil were recruited. Patient's clinical and epidemiological data were recorded. Nasopharyngeal swab and tracheal aspirate samples were collected to extract viral nucleic acid. RSV, adenovirus, rhinovirus, FluA, HMPV, HCoV-OC43 and HCoV-NL63 were detected by real-time polymerase chain reaction. The severe CAP was associated with ages between 3 and 12 months. Viruses were detected in 43% of CAP patients. Rhinovirus infections were the most frequently identified (68%). RSV, adenovirus, FluA, and co-infections were identified in 14, 14, 5, and 15% of children with viral infection, respectively. Rhinovirus was associated with non-severe CAP (p = 0.014); RSV, FluA, and co-infections were associated with severe CAP (p < 0.05). New strategies for prevention and treatment of viral respiratory infections, mainly rhinovirus and RSV infections, are necessary. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Epidemiology; Respiratory tract; Seasonal incidence
PMID: 31230362 DOI: 10.1002/jmv.25524
High incidence of rhinovirus infection in children with community acquired pneumonia from a city in the Brazilian pre-Amazon region.
Dos Santos Ferreira HL1, Costa KLP1, Cariolano MS1, Oliveira GS1, Felipe KKP1, Silva ESA1, Alves MS1, Maramaldo CEC1, de Sousa EM1, Rego JS2, Silva ICPA1, Albuquerque RKS3, Ara?jo NSC3, Amorim AMM3, Costa LD3, Pinheiro CS3, Guimar?es VA4, Santos MC5, Mello WA5, Falcai A6, Lima-Neto LG1.
Author information
Abstract
Community-acquired pneumonia (CAP) is the leading cause of child death worldwide. Viruses are the most common pathogens associated with CAP in children, but their incidence varies greatly. This study investigated the presence of respiratory syncytial virus (RSV), adenovirus, human rhinovirus (HRV), human metapneumovirus (HMPV), human coronavirus (HCoV-OC43 and HCoV-NL63), and influenza A virus (FluA) in children with CAP and the contributing risk factors. Here, children with acute respiratory infections were screened by pediatrics; and a total of 150 radiographically-confirmed CAP patients (aged 3 months to 10 years) from two clinical centers in Sao Luis, Brazil were recruited. Patient's clinical and epidemiological data were recorded. Nasopharyngeal swab and tracheal aspirate samples were collected to extract viral nucleic acid. RSV, adenovirus, rhinovirus, FluA, HMPV, HCoV-OC43 and HCoV-NL63 were detected by real-time polymerase chain reaction. The severe CAP was associated with ages between 3 and 12 months. Viruses were detected in 43% of CAP patients. Rhinovirus infections were the most frequently identified (68%). RSV, adenovirus, FluA, and co-infections were identified in 14, 14, 5, and 15% of children with viral infection, respectively. Rhinovirus was associated with non-severe CAP (p = 0.014); RSV, FluA, and co-infections were associated with severe CAP (p < 0.05). New strategies for prevention and treatment of viral respiratory infections, mainly rhinovirus and RSV infections, are necessary. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Epidemiology; Respiratory tract; Seasonal incidence
PMID: 31230362 DOI: 10.1002/jmv.25524