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Isolation and characterization of H5Nx highly pathogenic avian influenza viruses of clade 2.3.4.4 in Russia

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  • Isolation and characterization of H5Nx highly pathogenic avian influenza viruses of clade 2.3.4.4 in Russia

    Virology. 2018 Oct 5;525:216-223. doi: 10.1016/j.virol.2018.09.024. [Epub ahead of print]
    Isolation and characterization of H5Nx highly pathogenic avian influenza viruses of clade 2.3.4.4 in Russia.

    Marchenko V1, Goncharova N2, Susloparov I2, Kolosova N2, Gudymo A2, Svyatchenko S2, Danilenko A2, Durymanov A2, Gavrilova E2, Maksyutov R2, Ryzhikov A2.
    Author information

    Abstract

    In 2016-2017, several subtypes of the highly pathogenic avian influenza (HPAI) virus were isolated on the territory of Russia. In the autumn of 2016, during the avian influenza virus surveillance in the territory of the Kamchatka region of Russia the HPAI A(H5N5) influenza virus was isolated. Then, during 2016-2017, multiple outbreaks among wild birds and poultry caused by HPAI A(H5N8) avian influenza virus were recorded in European part of Russia. At the end of 2017, an outbreak among poultry caused by HPAI A(H5N2) influenza virus was recorded in the European part of Russia. Phylogenetic analysis of HA of the A(H5N5), A(H5N8), A(H5N2) showed the strains belong to the clade 2.3.4.4 b. All isolated strains were antigenically closely related to candidate vaccine viruses of clade 2.3.4.4 and showed high virulence in mice. Genetic analysis revealed presence of genetic markers potentially related to high virulence in mice in all studied viruses.


    KEYWORDS:

    Avian influenza; H5N2; H5N5; H5N8; HPAI; Russia; Surveillance

    PMID: 30296682 DOI: 10.1016/j.virol.2018.09.024
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