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Viruses. 2018 Aug 3;10(8). pii: E407. doi: 10.3390/v10080407.
Mutation and Epistasis in Influenza Virus Evolution.
Lyons DM1, Lauring AS2,3,4.
Author information
Abstract
Influenza remains a persistent public health challenge, because the rapid evolution of influenza viruses has led to marginal vaccine efficacy, antiviral resistance, and the annual emergence of novel strains. This evolvability is driven, in part, by the virus's capacity to generate diversity through mutation and reassortment. Because many new traits require multiple mutations and mutations are frequently combined by reassortment, epistatic interactions between mutations play an important role in influenza virus evolution. While mutation and epistasis are fundamental to the adaptability of influenza viruses, they also constrain the evolutionary process in important ways. Here, we review recent work on mutational effects and epistasis in influenza viruses.
KEYWORDS:
epistasis; evolution; influenza; mutation; reassortment
PMID: 30081492 DOI: 10.3390/v10080407
Free full text
Mutation and Epistasis in Influenza Virus Evolution.
Lyons DM1, Lauring AS2,3,4.
Author information
Abstract
Influenza remains a persistent public health challenge, because the rapid evolution of influenza viruses has led to marginal vaccine efficacy, antiviral resistance, and the annual emergence of novel strains. This evolvability is driven, in part, by the virus's capacity to generate diversity through mutation and reassortment. Because many new traits require multiple mutations and mutations are frequently combined by reassortment, epistatic interactions between mutations play an important role in influenza virus evolution. While mutation and epistasis are fundamental to the adaptability of influenza viruses, they also constrain the evolutionary process in important ways. Here, we review recent work on mutational effects and epistasis in influenza viruses.
KEYWORDS:
epistasis; evolution; influenza; mutation; reassortment
PMID: 30081492 DOI: 10.3390/v10080407
Free full text