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PLoS One. 2016 Mar 9;11(3):e0150713. doi: 10.1371/journal.pone.0150713. eCollection 2016.
Epidemiology, Seasonality and Treatment of Hospitalized Adults and Adolescents with Influenza in Jingzhou, China, 2010-2012.
Zheng J1, Huo X2, Huai Y3, Xiao L4, Jiang H1, Klena J3,5, Greene CM3,6, Xing X2, Huang J4, Liu S7, Peng Y8, Yang H9, Luo J10, Peng Z1, Liu L2, Chen M4, Chen H2, Zhang Y3, Huang D2, Guan X2, Feng L1, Zhan F2, Hu DJ3,5,11, Varma JK3,5, Yu H1.
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Abstract
BACKGROUND:
After the 2009 influenza A (H1N1) pandemic, we conducted hospital-based severe acute respiratory infection (SARI) surveillance in one central Chinese city to assess disease burden attributable to influenza among adults and adolescents.
METHODS:
We defined an adult SARI case as a hospitalized patient aged ≥ 15 years with temperature ≥38.0?C and at least one of the following: cough, sore throat, tachypnea, difficulty breathing, abnormal breath sounds on auscultation, sputum production, hemoptysis, chest pain, or chest radiograph consistent with pneumonia. For each enrolled SARI case-patient, we completed a standardized case report form, and collected a nasopharyngeal swab within 24 hours of admission. Specimens were tested for influenza viruses by real-time reverse transcription polymerase chain reaction (rRT-PCR). We analyzed data from adult SARI cases in four hospitals in Jingzhou, China from April 2010 to April 2012.
RESULTS:
Of 1,790 adult SARI patients enrolled, 40% were aged ≥ 65 years old. The median duration of hospitalization was 9 days. Nearly all were prescribed antibiotics during their hospitalization, less than 1% were prescribed oseltamivir, and 28% were prescribed corticosteroids. Only 0.1% reported receiving influenza vaccination in the past year. Of 1,704 samples tested, 16% were positive for influenza. Influenza activity in all age groups showed winter-spring and summer peaks. Influenza-positive patients had a longer duration from illness onset to hospitalization and a shorter duration from hospital admission to discharge or death compared to influenza negative SARI patients.
CONCLUSIONS:
There is substantial burden of influenza-associated SARI hospitalizations in Jingzhou, China, especially among older adults. More effective promotion of annual seasonal influenza vaccination and timely oseltamivir treatment among high risk groups may improve influenza prevention and control in China.
PMID: 26958855 [PubMed - in process] Free full text
Epidemiology, Seasonality and Treatment of Hospitalized Adults and Adolescents with Influenza in Jingzhou, China, 2010-2012.
Zheng J1, Huo X2, Huai Y3, Xiao L4, Jiang H1, Klena J3,5, Greene CM3,6, Xing X2, Huang J4, Liu S7, Peng Y8, Yang H9, Luo J10, Peng Z1, Liu L2, Chen M4, Chen H2, Zhang Y3, Huang D2, Guan X2, Feng L1, Zhan F2, Hu DJ3,5,11, Varma JK3,5, Yu H1.
Author information
Abstract
BACKGROUND:
After the 2009 influenza A (H1N1) pandemic, we conducted hospital-based severe acute respiratory infection (SARI) surveillance in one central Chinese city to assess disease burden attributable to influenza among adults and adolescents.
METHODS:
We defined an adult SARI case as a hospitalized patient aged ≥ 15 years with temperature ≥38.0?C and at least one of the following: cough, sore throat, tachypnea, difficulty breathing, abnormal breath sounds on auscultation, sputum production, hemoptysis, chest pain, or chest radiograph consistent with pneumonia. For each enrolled SARI case-patient, we completed a standardized case report form, and collected a nasopharyngeal swab within 24 hours of admission. Specimens were tested for influenza viruses by real-time reverse transcription polymerase chain reaction (rRT-PCR). We analyzed data from adult SARI cases in four hospitals in Jingzhou, China from April 2010 to April 2012.
RESULTS:
Of 1,790 adult SARI patients enrolled, 40% were aged ≥ 65 years old. The median duration of hospitalization was 9 days. Nearly all were prescribed antibiotics during their hospitalization, less than 1% were prescribed oseltamivir, and 28% were prescribed corticosteroids. Only 0.1% reported receiving influenza vaccination in the past year. Of 1,704 samples tested, 16% were positive for influenza. Influenza activity in all age groups showed winter-spring and summer peaks. Influenza-positive patients had a longer duration from illness onset to hospitalization and a shorter duration from hospital admission to discharge or death compared to influenza negative SARI patients.
CONCLUSIONS:
There is substantial burden of influenza-associated SARI hospitalizations in Jingzhou, China, especially among older adults. More effective promotion of annual seasonal influenza vaccination and timely oseltamivir treatment among high risk groups may improve influenza prevention and control in China.
PMID: 26958855 [PubMed - in process] Free full text