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Infect Genet Evol. 2014 Dec 27. pii: S1567-1348(14)00482-1. doi: 10.1016/j.meegid.2014.12.026. [Epub ahead of print]
Identification of the source of A (H10N8) virus causing human infection.
Xu Y1, Cao H2, Liu H2, Sun H3, Martin B3, Zhao Y3, Wang Q2, Deng G2, Xue J3, Zong Y2, Zhu J2, Wen F3, Long L3, Wong S4, Zhao N3, Fu X5, Liao M6, Hu G7, Webby R4, Gao GF8, Wan X9.
Author information
Abstract
A novel H10N8 influenza A virus has been detected in three humans in China since December 2013. Although this virus was hypothesized to be a novel reassortant among influenza viruses from wild birds and domestic poultry, its evolutionary path leading to human infection is unknown. Sporadic surveillance at the live poultry market (LPM) suspected to be the source of infection for the first H10N8 patient has shown a gradual increase in influenza virus prevalence culminating with a predominance of H10N8 viruses. Influenza viruses detected in the LPM up to 8 months prior to human infection contributed genetic components to the zoonotic virus. These H10N8 viruses have continued to evolve within this LPM subsequent to the human infection, and continuous assessments of these H10N8 viruses will be necessary. Serological surveillance showed that the virus appears to have been present throughout the LPM system in Nanchang, China. Reduction of the influenza virus burden in LPMs is essential in preventing future emergence of novel influenza viruses with zoonotic and pandemic potential.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Avian influenza virus; H10N8; Human infection; Live poultry market
PMID: 25550151 [PubMed - as supplied by publisher]
Identification of the source of A (H10N8) virus causing human infection.
Xu Y1, Cao H2, Liu H2, Sun H3, Martin B3, Zhao Y3, Wang Q2, Deng G2, Xue J3, Zong Y2, Zhu J2, Wen F3, Long L3, Wong S4, Zhao N3, Fu X5, Liao M6, Hu G7, Webby R4, Gao GF8, Wan X9.
Author information
Abstract
A novel H10N8 influenza A virus has been detected in three humans in China since December 2013. Although this virus was hypothesized to be a novel reassortant among influenza viruses from wild birds and domestic poultry, its evolutionary path leading to human infection is unknown. Sporadic surveillance at the live poultry market (LPM) suspected to be the source of infection for the first H10N8 patient has shown a gradual increase in influenza virus prevalence culminating with a predominance of H10N8 viruses. Influenza viruses detected in the LPM up to 8 months prior to human infection contributed genetic components to the zoonotic virus. These H10N8 viruses have continued to evolve within this LPM subsequent to the human infection, and continuous assessments of these H10N8 viruses will be necessary. Serological surveillance showed that the virus appears to have been present throughout the LPM system in Nanchang, China. Reduction of the influenza virus burden in LPMs is essential in preventing future emergence of novel influenza viruses with zoonotic and pandemic potential.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Avian influenza virus; H10N8; Human infection; Live poultry market
PMID: 25550151 [PubMed - as supplied by publisher]
