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Comput Biol Med. 2014 Jun 16;52C:35-40. doi: 10.1016/j.compbiomed.2014.06.003. [Epub ahead of print]
SimFlu: A simulation tool for predicting the variation pattern of influenza A virus.
Ahn I1, Kim HY2, Jung S3, Lee JH4, Son HS5.
Author information
Abstract
Since the first pandemic outbreak of avian influenza A virus (H5N1 subtype) in 1997, the National Center for Biotechnology Information (NCBI) has provided a large number of influenza virus sequences with well-organized annotations. Using the time-series sequences of influenza A viruses, we developed a simulation tool for influenza virus, named SimFlu, to predict possible future variants of influenza viruses. SimFlu can create variants from a seed nucleotide sequence of influenza A virus using the codon variation parameters included in the SimFlu package. The SimFlu library provides pre-calculated codon variation parameters for the H1N1, H3N2, and H5N1 subtypes of influenza A virus isolated from 2000 to 2011, allowing the users to simulate their own nucleotide sequences by selecting their preferred parameter options. SimFlu supports three operating systems - Windows, Linux, and Mac OS X. SimFlu is publicly available at http://lcbb.snu.ac.kr/simflu.
Copyright ? 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
KEYWORDS:
Bioinformatics; Codon variation; Influenza A virus; Pattern prediction; Simulation
PMID:
24995426
[PubMed - as supplied by publisher]
Free full text
SimFlu: A simulation tool for predicting the variation pattern of influenza A virus.
Ahn I1, Kim HY2, Jung S3, Lee JH4, Son HS5.
Author information
Abstract
Since the first pandemic outbreak of avian influenza A virus (H5N1 subtype) in 1997, the National Center for Biotechnology Information (NCBI) has provided a large number of influenza virus sequences with well-organized annotations. Using the time-series sequences of influenza A viruses, we developed a simulation tool for influenza virus, named SimFlu, to predict possible future variants of influenza viruses. SimFlu can create variants from a seed nucleotide sequence of influenza A virus using the codon variation parameters included in the SimFlu package. The SimFlu library provides pre-calculated codon variation parameters for the H1N1, H3N2, and H5N1 subtypes of influenza A virus isolated from 2000 to 2011, allowing the users to simulate their own nucleotide sequences by selecting their preferred parameter options. SimFlu supports three operating systems - Windows, Linux, and Mac OS X. SimFlu is publicly available at http://lcbb.snu.ac.kr/simflu.
Copyright ? 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
KEYWORDS:
Bioinformatics; Codon variation; Influenza A virus; Pattern prediction; Simulation
PMID:
24995426
[PubMed - as supplied by publisher]
Free full text
