Genome Sequence of a Novel H10N9 Avian Influenza Virus Isolated from Chickens in a Live Poultry Market in Eastern China

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Genome Announc. 2013 Jun 27;1(4). pii: e00386-13. doi: 10.1128/genomeA.00386-13.
Genome Sequence of a Novel H10N9 Avian Influenza Virus Isolated from Chickens in a Live Poultry Market in Eastern China.
Su C, Chen S, Liu X, Xu J, Huang K, Liu K, Huang J, Peng D, Liu X.
Source

Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China; Ministry of Education, Key Lab for Avian Preventive Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
Abstract

An H10N9 avian influenza virus (AIV) strain, A/Chicken/Jiangsu/RD5/2013, was isolated in China. The hemagglutinin (HA) and neuraminidase (NA) genes in this strain originated from H10N1 and H7N9 AIVs, respectively, and the other genes derived from H7N3 AIVs. Sequence analysis implies that the H10N9 AIV may be an NA gene donor for the human H7N9 influenza viruses.

PMID:
23814107
[PubMed]
PMCID:
PMC3695435

Free full text

http://www.ncbi.nlm.nih.gov/pubmed/23814107

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Re: Genome Sequence of a Novel H10N9 Avian Influenza Virus Isolated from Chickens in a Live Poultry Market in Eastern China

full text here: http://genomea.asm.org/content/1/4/e00386-13.full

from the article -

A new emerging H7N9 influenza virus subtype has become a significant public health threat. . . . To date, the H7N9 influenza virus has not acquired a consistent ability to transmit from human to human, but H7N9 AIV infections from birds to humans are associated with live poultry markets. Recently, H7N9, H10N9, and H11N9 AIV subtypes have been isolated from wild birds. It is important to investigate whether these AIV subtypes exist in live poultry markets, which may provide an NA gene for the H7N9 influenza virus. . .

In conclusion, the CKRD5 virus is a reassortant with the HA and NA genes from wild bird origin H10N1 and H7N9 AIVs, respectively, and the other six genes from H7N3 AIVs. The CKRD5 virus may be an NA gene donor for the emerging H7N9 influenza viruses.