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Arch Virol. 2012 Oct 9. [Epub ahead of print]
Characterization of low-pathogenic H6N6 avian influenza viruses in central China.
Yao Y, Wang H, Chen Q, Zhang H, Zhang T, Chen J, Xu B, Wang H, Sun B, Chen Z.
Source
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, Hubei, China.
Abstract
Three strains of H6N6 subtype avian influenza virus (AIV) were isolated from live-poultry markets of central China during 2009-2010. A phylogenetic analysis showed that these isolates originated from gene reassortment among different virus lineages of the H6 subtype. In an experimental infection of animals, the selected isolate was non-pathogenic for chickens and low-pathogenic for mice. The wild-type isolate was capable of replication in mouse lung without prior adaptation, and the virulence to mice increased rapidly during adaption in mouse lung. The genomes of viruses of passage 0 (P0), P4, and P8 were sequenced and compared, and virulence-related amino acid substitutions were found in multiple sites during mouse lung passage.
PMID:
23053524
[PubMed - as supplied by publisher]
Characterization of low-pathogenic H6N6 avian influenza viruses in central China.
Yao Y, Wang H, Chen Q, Zhang H, Zhang T, Chen J, Xu B, Wang H, Sun B, Chen Z.
Source
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, Hubei, China.
Abstract
Three strains of H6N6 subtype avian influenza virus (AIV) were isolated from live-poultry markets of central China during 2009-2010. A phylogenetic analysis showed that these isolates originated from gene reassortment among different virus lineages of the H6 subtype. In an experimental infection of animals, the selected isolate was non-pathogenic for chickens and low-pathogenic for mice. The wild-type isolate was capable of replication in mouse lung without prior adaptation, and the virulence to mice increased rapidly during adaption in mouse lung. The genomes of viruses of passage 0 (P0), P4, and P8 were sequenced and compared, and virulence-related amino acid substitutions were found in multiple sites during mouse lung passage.
PMID:
23053524
[PubMed - as supplied by publisher]
