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Microbes Infect. 2011 Feb 1. [Epub ahead of print]
Immunity to seasonal and pandemic influenza A viruses.
Valkenburg SA, Rutigliano JA, Ellebedy AH, Doherty PC, Thomas PG, Kedzierska K.
Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Melbourne, Australia.
Abstract
The introduction of a new influenza strain into human circulation leads to rapid global spread. This review summarizes innate and adaptive immunity to influenza viruses, with an emphasis on T-cell responses that provide cross-protection between distinct subtypes and strains. We discuss antigenic variation within T-cell immunogenic peptides and our understanding of pre-existing immunity towards the pandemic A(H1N1) 2009 strain.
Copyright ? 2011 Institut Pasteur. All rights reserved.
PMID: 21295153 [PubMed - as supplied by publisher]
Immunity to seasonal and pandemic influenza A viruses.
Valkenburg SA, Rutigliano JA, Ellebedy AH, Doherty PC, Thomas PG, Kedzierska K.
Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Melbourne, Australia.
Abstract
The introduction of a new influenza strain into human circulation leads to rapid global spread. This review summarizes innate and adaptive immunity to influenza viruses, with an emphasis on T-cell responses that provide cross-protection between distinct subtypes and strains. We discuss antigenic variation within T-cell immunogenic peptides and our understanding of pre-existing immunity towards the pandemic A(H1N1) 2009 strain.
Copyright ? 2011 Institut Pasteur. All rights reserved.
PMID: 21295153 [PubMed - as supplied by publisher]
