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MBio. 2014 Dec 12;5(6). pii: e02430-14. doi: 10.1128/mBio.02430-14.
Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness.
Schultz-Cherry S1, Webby RJ2, Webster RG2, Kelso A3, Barr IG3, McCauley JW4, Daniels RS4, Wang D5, Shu Y5, Nobusawa E6, Itamura S6, Tashiro M6, Harada Y6, Watanabe S6, Odagiri T6, Ye Z7, Grohmann G8, Harvey R9, Engelhardt O9, Smith D10, Hamilton K11, Claes F12, Dauphin G12.
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Abstract
In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process-from selection of candidate vaccine viruses (CVVs) to the manufacture and stockpiling of safe, high-yield prepandemic vaccines for the global community. The article is not written to support a specific pro- or anti-GOF stance but rather to inform the scientific community about factors involved in vaccine virus selection and the preparation of prepandemic influenza vaccines and the impact that some GOF information has had on this process.
Copyright ? 2014 Schultz-Cherry et al.
PMID: 25505124 [PubMed - in process] Free full text
Influenza Gain-of-Function Experiments: Their Role in Vaccine Virus Recommendation and Pandemic Preparedness.
Schultz-Cherry S1, Webby RJ2, Webster RG2, Kelso A3, Barr IG3, McCauley JW4, Daniels RS4, Wang D5, Shu Y5, Nobusawa E6, Itamura S6, Tashiro M6, Harada Y6, Watanabe S6, Odagiri T6, Ye Z7, Grohmann G8, Harvey R9, Engelhardt O9, Smith D10, Hamilton K11, Claes F12, Dauphin G12.
Author information
Abstract
In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process-from selection of candidate vaccine viruses (CVVs) to the manufacture and stockpiling of safe, high-yield prepandemic vaccines for the global community. The article is not written to support a specific pro- or anti-GOF stance but rather to inform the scientific community about factors involved in vaccine virus selection and the preparation of prepandemic influenza vaccines and the impact that some GOF information has had on this process.
Copyright ? 2014 Schultz-Cherry et al.
PMID: 25505124 [PubMed - in process] Free full text