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Open Heart
. 2024 May 27;11(1):e002662.
doi: 10.1136/openhrt-2024-002662. Long COVID and cardiovascular disease: a prospective cohort study
Claire Alexandra Lawson 1 , Alastair James Moss 1 , Jayanth Ranjit Arnold 1 , Catherine Bagot 2 , Amitava Banerjee 3 , Colin Berry 4 5 , John Greenwood 6 7 , Alun D Hughes 8 , Kamlesh Khunti 9 , Nicholas L Mills 10 , Stefan Neubauer 11 , Betty Raman 11 , Naveed Sattar 12 , Olivia C Leavy 13 , Matthew Richardson 14 , Omer Elneima 14 , Hamish Jc McAuley 14 , Aarti Shikotra 14 , Amisha Singapuri 14 , Marco Sereno 14 , Ruth Saunders 14 , Victoria Harris 14 , Linzy Houchen-Wolloff 14 , Neil J Greening 14 , Ewen Harrison 15 , Annemarie B Docherty 15 , Nazir I Lone 15 , Jennifer Kathleen Quint 16 , James Chalmers 17 , Ling-Pei Ho 18 , Alex Horsley 19 , Michael Marks 20 , Krisnah Poinasamy 21 , Rachael Evans 22 , Louise V Wain 13 , Chris Brightling 22 , Gerry P McCann 23 ; PHOSP-COVID Study Collaborative Group
Collaborators, Affiliations
Background: Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known.
Objectives: To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors.
Methods: In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health.
Results: From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86).
Conclusion: Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need.
Trail registration number: ISRCTN10980107.
Keywords: CARDIAC REHABILITATION; COVID-19; RISK FACTORS.
. 2024 May 27;11(1):e002662.
doi: 10.1136/openhrt-2024-002662. Long COVID and cardiovascular disease: a prospective cohort study
Claire Alexandra Lawson 1 , Alastair James Moss 1 , Jayanth Ranjit Arnold 1 , Catherine Bagot 2 , Amitava Banerjee 3 , Colin Berry 4 5 , John Greenwood 6 7 , Alun D Hughes 8 , Kamlesh Khunti 9 , Nicholas L Mills 10 , Stefan Neubauer 11 , Betty Raman 11 , Naveed Sattar 12 , Olivia C Leavy 13 , Matthew Richardson 14 , Omer Elneima 14 , Hamish Jc McAuley 14 , Aarti Shikotra 14 , Amisha Singapuri 14 , Marco Sereno 14 , Ruth Saunders 14 , Victoria Harris 14 , Linzy Houchen-Wolloff 14 , Neil J Greening 14 , Ewen Harrison 15 , Annemarie B Docherty 15 , Nazir I Lone 15 , Jennifer Kathleen Quint 16 , James Chalmers 17 , Ling-Pei Ho 18 , Alex Horsley 19 , Michael Marks 20 , Krisnah Poinasamy 21 , Rachael Evans 22 , Louise V Wain 13 , Chris Brightling 22 , Gerry P McCann 23 ; PHOSP-COVID Study Collaborative Group
Collaborators, Affiliations
- PMID: 38802280
- DOI: 10.1136/openhrt-2024-002662
Background: Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known.
Objectives: To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors.
Methods: In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health.
Results: From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86).
Conclusion: Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need.
Trail registration number: ISRCTN10980107.
Keywords: CARDIAC REHABILITATION; COVID-19; RISK FACTORS.