J Diabetes . Type 1 diabetes mellitus and SARS-CoV-2 in pediatric and adult patients - Data from the DPV network

[tetano]

J Diabetes


. 2022 Nov;14(11):758-766.
doi: 10.1111/1753-0407.13332.
Type 1 diabetes mellitus and SARS-CoV-2 in pediatric and adult patients - Data from the DPV network


Bastian Raphael Büttner ¹ , Sascha René Tittel ^{2 3} , Clemens Kamrath ⁴ , Beate Karges ⁵ , Katharina Köstner ⁶ , Andreas Melmer ⁷ , Elke Müller-Roßberg ⁸ , Friederike Richter ⁹ , Tilman R Rohrer ¹ , Reinhard W Holl ^{2 3}



Affiliations

• PMID: 36443963
• DOI: 10.1111/1753-0407.13332

Abstract

in English, Chinese
Background: Data on patients with type 1 diabetes mellitus (T1DM) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are sparse. This study aimed to investigate the association between SARS-CoV-2 infection and T1DM.
Methods: Data from the Prospective Diabetes Follow-up (DPV) Registry were analyzed for diabetes patients tested for SARS-CoV-2 by polymerase chain reaction (PCR) in Germany, Austria, Switzerland, and Luxembourg during January 2020-June 2021, using Wilcoxon rank-sum and chi-square tests for continuous and dichotomous variables, adjusted for multiple testing.
Results: Data analysis of 1855 pediatric T1DM patients revealed no differences between asymptomatic/symptomatic infected and SARS-CoV-2 negative/positive patients regarding age, new-onset diabetes, diabetes duration, and body mass index. Glycated hemoglobin A1c (HbA1c) and diabetic ketoacidosis (DKA) rate were not elevated in SARS-CoV-2-positive vs. -negative patients. The COVID-19 manifestation index was 37.5% in individuals with known T1DM, but 57.1% in individuals with new-onset diabetes. 68.8% of positively tested patients were managed as outpatients/telemedically. Data analysis of 240 adult T1MD patients revealed no differences between positively and negatively tested patients except lower HbA1c. Of these patients, 83.3% had symptomatic infections; 35.7% of positively tested patients were hospitalized.
Conclusions: Our results indicate low morbidity in SARS-CoV-2-infected pediatric T1DM patients. Most patients with known T1DM and SARS-CoV-2 infections could be managed as outpatients. However, SARS-CoV-2 infection was usually symptomatic if it coincided with new-onset diabetes. In adult patients, symptomatic SARS-CoV-2 infection and hospitalization were associated with age.

Keywords: 1型糖尿病; COVID-19; DPV database; SARS-CoV-2; diabetic ketoacidosis; type 1 diabetes mellitus; 严重急性呼吸综合征冠状病毒2型; 前瞻性糖尿病随访数据; 新冠肺炎; 糖尿病酮症酸中毒.