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Obstet Gynecol
. 2022 Aug 1;140(2):262-265.
doi: 10.1097/AOG.0000000000004849. Epub 2022 May 18.
Maternal and Perinatal Outcomes Associated With the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection
Angela R Seasely 1 , Christina T Blanchard, Nitin Arora, Ashley N Battarbee, Brian M Casey, Jodie Dionne-Odom, Sixto M Leal Jr, Derek B Moates, Rachel G Sinkey, Jeff M Szychowski, Alan T Tita, Akila Subramaniam, CWRH's COVID-19 Working Group
Affiliations
- PMID: 35852277
- DOI: 10.1097/AOG.0000000000004849
Abstract
Two years into the coronavirus disease 2019 (COVID-19) pandemic, we have now seen three main variant waves. We performed a retrospective cohort study of all pregnant patients with COVID-19 at our institution from March 22, 2020, to February 26, 2022, to evaluate disease severity and perinatal outcomes among the variants. Patients were categorized as pre-Delta (March 22, 2020-May 31, 2021), Delta (July 1, 2021-December 15, 2021), or Omicron (December 16, 2021- February 26, 2022) based on variant tracking from the Centers for Disease Control and Prevention and genotype sequencing at our institution. There were fewer cases of severe-critical disease (1.8% Omicron vs 13.3% pre-Delta and 24.1% Delta) and adverse perinatal outcomes during the Omicron wave compared with the pre-Delta and Delta waves.