Pediatr Infect Dis J . Recurrent SARS-CoV-2 Infection and Impaired Immunologic Response in a Pediatric Oncologic Patient While Treated With Radiochemotherapy

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Pediatr Infect Dis J


. 2022 Apr 21.
doi: 10.1097/INF.0000000000003515. Online ahead of print.
Recurrent SARS-CoV-2 Infection and Impaired Immunologic Response in a Pediatric Oncologic Patient While Treated With Radiochemotherapy


Thomas Eichholz ¹ , Anne-Marie Arendt ¹ , Ursula Holzer ¹ , Christian Seitz ¹ , Armin Rabsteyn ¹ , Tina Ganzenmueller ² , Reinhild Klein ³ , Juliane Walz ^{4 5 6 7} , Peter Lang ¹



Affiliations

• PMID: 35446806
• DOI: 10.1097/INF.0000000000003515

Abstract

Immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pediatric patients with malignant disease may be affected by tumor therapy. Here, we report the case of a child with rhabdomyosarcoma and recurrent SARS-CoV-2 infection. Immunologic responses, analyzed by T-cell activity and anti-viral IgG levels, were impaired and not durable as a result of intensive radiochemotherapy.