J Pediatr . Acute Necrotizing Encephalopathy Associated with Coronavirus Disease 2019 in an Infant

[tetano]

J Pediatr


. 2022 Apr 18;S0022-3476(22)00346-8.
doi: 10.1016/j.jpeds.2022.04.031. Online ahead of print.
Acute Necrotizing Encephalopathy Associated with Coronavirus Disease 2019 in an Infant


Mariha Khan ¹ , Samhita Bhattarai ¹ , Thomas G Boyce ¹ , Reyaad A Hayek ² , Sergey I Zhadanov ² , Elisabeth E Hooper ¹ , Edward G Fernandez ¹ , Monica A Koehn ³



Affiliations

• PMID: 35447125
• DOI: 10.1016/j.jpeds.2022.04.031

Abstract

A 5-week-old infant born at term was diagnosed with acute necrotizing encephalopathy associated with SARS-CoV-2 as evidenced by clinical presentation, neuroimaging, and cerebrospinal fluid studies. Our patient was treated with high dose intravenous methylprednisolone, tocilizumab and intravenous immunoglobulin with significant short-term clinical improvement but long-term sequelae.