Gastroenterol Hepatol Bed Bench . Gut microbiota, angiotensin-converting enzyme, celiac disease, and risk of COVID-19 infection: a review

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Gastroenterol Hepatol Bed Bench


. Fall 2021;14(Suppl1):S24-S31.

Gut microbiota, angiotensin-converting enzyme, celiac disease, and risk of COVID-19 infection: a review


Fahimeh Sadat Gholam-Mostafaei ¹ , Tina Didari ^{2 3} , Marzieh Ramandi ⁴ , Reza Vafaee ⁵ , Mohammad Rostami-Nejad ¹



Affiliations

• PMID: 35154599
• PMCID: PMC8817746

Abstract

Celiac disease (CD) is an autoimmune disorder of the gastrointestinal tract in a genetically susceptible person. Gluten is the most crucial trigger factor for CD, and environmental factors such as microbiota and opportunistic infection risk its pathogenesis. Coronavirus disease 19 (COVID-19) spread rapidly and became a problem for healthcare systems worldwide. Little is known about the risk of severe COVID-19 and the role of dysbiosis among patients with CD. There is also a lack of knowledge about the effects of CD gut microbiota on COVID-19 infection. Therefore, the current review discusses the relationship between CD and risk factors such as microbiota for susceptibility to COVID-19.

Keywords: ACE2 receptor; COVID-19; Celiac disease; Gut microbiota; SARS-CoV-2.