JACC Case Rep . Giant Coronary Aneurysms in Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection

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JACC Case Rep


. 2021 Oct 6;3(13):1499-1508.
doi: 10.1016/j.jaccas.2021.06.043.
Giant Coronary Aneurysms in Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection


D Sofia Villacis-Nunez ^{1 2} , Sassan Hashemi ^{2 3} , Meghan C Nelson ^{1 2} , Elaine Flanagan ^{1 2} , Amit Thakral ^{1 2} , Fred Rodriguez 3rd ^{2 3} , Preeti Jaggi ^{2 4} , Matthew E Oster ^{2 3} , Sampath Prahalad ^{1 2 5} , Kelly A Rouster-Stevens ^{1 2}



Affiliations

• PMID: 34642670
• PMCID: PMC8494056
• DOI: 10.1016/j.jaccas.2021.06.043

Abstract

Multisystem inflammatory syndrome in children (MIS-C) can cause a myriad of cardiac manifestations, including coronary dilation and aneurysms; giant aneurysms are infrequent. We describe 3patients with giant coronary aneurysms associated with MIS-C, including the youngest case reported to date, treated with intravenous immunoglobulin, corticosteroids, and biologic agents. (Level of Difficulty: Intermediate.).

Keywords: COVID-19; IVIG, intravenous immunoglobulin; IVMP, intravenous methylprednisolone; IgG, immunoglobulin G; KD, Kawasaki disease; LAD, left anterior descending; MIS-C, multisystem inflammatory syndrome in children; PCR, polymerase chain reaction; RCA, right coronary artery; SARS-CoV-2; SARS-CoV-2, severe acute respiratory distress syndrome-coronavirus-2; giant coronary aneurysms; multisystem inflammatory syndrome in children.