J Neurovirol . A case-based systematic review on the SARS-COVID-2-associated cerebrovascular diseases and the possible virus routes of entry

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J Neurovirol


. 2021 Sep 21.
doi: 10.1007/s13365-021-01013-8. Online ahead of print.
A case-based systematic review on the SARS-COVID-2-associated cerebrovascular diseases and the possible virus routes of entry


Ali Lashkari ¹ , Reza Ranjbar ²



Affiliations

• PMID: 34546547
• DOI: 10.1007/s13365-021-01013-8

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sparked a global pandemic that continues to affect various facets of human existence. Many sources reported virus-induced acute cerebrovascular disorders. Systematically, this paper reviews the case studies of COVID-19-related acute cerebrovascular diseases such as ischaemic stroke, intracerebral hemorrhage, and cerebral sinus thrombosis. We also spoke about how SARS-CoV-2 can infect the brain and trigger the aforementioned disorders. We stated that SARS-CoV-2 neuroinvasion and BBB dysfunction could cause the observed disorders; however, further research is required to specify the mechanisms and pathogenesis of the virus.

Keywords: COVID-19; Cerebral venous sinus thrombosis; Cerebrovascular; Intracranial hemorrhage; Ischemic stroke.