Open Forum Infect Dis . Coronavirus Disease 2019 in a Patient With a Systemic Autoinflammatory Syndrome due to an NLRC4 Inflammasomopathy

[tetano]

Open Forum Infect Dis


. 2021 Jul 5;8(8):ofab362.
doi: 10.1093/ofid/ofab362. eCollection 2021 Aug.
Coronavirus Disease 2019 in a Patient With a Systemic Autoinflammatory Syndrome due to an NLRC4 Inflammasomopathy


Jeffrey K Duncan-Lowey ^{1 2} , Vaidehi Chowdhary ³ , Dana W Dunne ¹



Affiliations

• PMID: 34377730
• PMCID: PMC8339282
• DOI: 10.1093/ofid/ofab362

Abstract

The effect of autoinflammatory diseases on severe acute respiratory syndrome coronavirus 2 infection remains unknown. We report a case of coronavirus disease 2019 (COVID-19) in a patient with autoinflammation with infantile enterocolitis with inflammatory flares due to a mutation in the inflammasome component NLRC4. This case highlights the role of immunosuppression in patients with autoinflammation with COVID-19.

Keywords: COVID-19; NLRC4; SARS-CoV-2; autoinflammatory; inflammasome.