Viruses . Relationships between Viral Load and the Clinical Course of COVID-19

[tetano]

Viruses


. 2021 Feb 15;13(2):304.
doi: 10.3390/v13020304.
Relationships between Viral Load and the Clinical Course of COVID-19


Hiroyuki Tsukagoshi ¹ , Daisuke Shinoda ¹ , Mariko Saito ¹ , Kaori Okayama ² , Mitsuru Sada ^{2 3} , Hirokazu Kimura ² , Nobuhiro Saruki ¹



Affiliations

• PMID: 33672005
• DOI: 10.3390/v13020304

Free article

Abstract

To predict the clinical outcome of coronavirus disease-2019 (COVID-19), we examined relationships among epidemiological data, viral load, and disease severity. We examined viral loads of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) in fatal (15 cases), symptomatic/survived (133 cases), and asymptomatic cases (138 cases) using reverse transcription quantitative real-time PCR (RT-qPCR). We examined 5768 nasopharyngeal swabs (NPS) and attempted to detect the SARS-CoV-2 genome using RT-qPCR. Among them, the viral genome was detected using the method for the 370 NPS samples with a positive rate of 6.4%. A comparison of each age showed that the fatal case was higher than the survived case and asymptomatic patients. Survived cases were older than asymptomatic patients. Notably, the viral load in the fatal cases was significantly higher than in symptomatic or asymptomatic cases (p < 0.05). These results suggested that a high viral load of the SARS-CoV-2 in elderly patients at an early stage of the disease results in a poor outcome. We should, therefore, intervene early to prevent a severe stage of the disease in such cases.

Keywords: clinical course; coronavirus disease-2019 (COVID-19); viral load.

[kiwibird]

https://www.hindawi.com/journals/bmri/2018/5703279/

The results of the present study revealed a significant association between folate level on admission and the duration of GBS progression. However, the role of folate deficiency in GBS is unclear.
...
5. Conclusions


In summary, we demonstrated that serum folate level is an independent marker associated with the duration of GBS progression. The roles of folate in GBS pathogenesis and prognosis need to be explored in prospective studies to monitor dynamic serum folate levels.