Front Cardiovasc Med . Microvascular Angiopathic Consequences of COVID-19

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Front Cardiovasc Med


. 2021 Feb 2;8:636843.
doi: 10.3389/fcvm.2021.636843. eCollection 2021.
Microvascular Angiopathic Consequences of COVID-19


Margaret Nalugo ¹ , Linda J Schulte ² , Muhammad F Masood ² , Mohamed A Zayed ^{1 3 4 5}



Affiliations

• PMID: 33604359
• PMCID: PMC7884319
• DOI: 10.3389/fcvm.2021.636843

Abstract

The coronavirus disease-2019 (COVID-19) pandemic has rapidly spread across the world. The disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first appeared in Wuhan, China in December, 2019. Ever increasing data is continuing to emerge about the impact of COVID-19 on cardiovascular tissue and other organ system. Clinical features associated with COVID-19 suggest that endothelial cell dysfunction and microvascular thrombosis are to a large extent contributing to resultant multi-organ complications. This review is aimed at highlighting the critical aspects associated with COVID-19 and its presumed microvascular angiopathic consequences on the cardiovascular system leading to multi-organ dysfunction.

Keywords: COVID-19; angiopathy; cardiac dysfunction; micovascular disease; vascular thrombosis.