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Infect Dis Now
. 2021 Jan 18.
doi: 10.1016/j.idnow.2021.01.005. Online ahead of print.
High incidence of Epstein-Barr virus, cytomegalovirus, and human-herpes virus-6 reactivations in critically-ill patients with Covid-19
Arthur Simonnet 1 , Ilka Engelmann 2 , Anne-Sophie Moreau 1 , Bruno Garcia 1 , Sophie Six 1 , Ahmed El Kalioubie 1 , Laurent Robriquet 1 , Didier Hober 2 , Merc? Jourdain 1
Affiliations
- PMID: 33495765
- PMCID: PMC7816954
- DOI: 10.1016/j.idnow.2021.01.005
Abstract
Background: Systemic reactivation of herpesviruses may occur in intensive care unit (ICU) patients and is associated with morbidity and mortality. Data on severe Coronavirus disease-19 (Covid-19) and concomitant reactivation of herpesviruses are lacking.
Methods: We selected patients admitted to ICU for confirmed Covid-19 who underwent systematic testing for Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human-herpes virus-6 (HHV-6) DNAemia while in the ICU. We retrospectively analyzed frequency, timing, duration and co-occurrence of viral DNAemia.
Results: Thirty-four patients were included. Viremia with EBV, CMV, and HHV-6 was detected in 28 (82%), 5 (15%), and 7 (22%) patients, respectively. EBV reactivation occurred early after ICU admission and was associated with longer ICU length-of-stay.
Conclusions: While in the ICU, critically-ill patients with Covid-19 are prone to develop reactivations due to various types of herpesviruses.
Keywords: Covid-19; Cytomegalovirus; Epstein -Barr virus.
Arthur Simonnet 1 , Ilka Engelmann 2 , Anne-Sophie Moreau 1 , Bruno Garcia 1 , Sophie Six 1 , Ahmed El Kalioubie 1 , Laurent Robriquet 1 , Didier Hober 2 , Merc? Jourdain 1
Affiliations
- PMID: 33495765
- PMCID: PMC7816954
- DOI: 10.1016/j.idnow.2021.01.005
Abstract
Background: Systemic reactivation of herpesviruses may occur in intensive care unit (ICU) patients and is associated with morbidity and mortality. Data on severe Coronavirus disease-19 (Covid-19) and concomitant reactivation of herpesviruses are lacking.
Methods: We selected patients admitted to ICU for confirmed Covid-19 who underwent systematic testing for Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human-herpes virus-6 (HHV-6) DNAemia while in the ICU. We retrospectively analyzed frequency, timing, duration and co-occurrence of viral DNAemia.
Results: Thirty-four patients were included. Viremia with EBV, CMV, and HHV-6 was detected in 28 (82%), 5 (15%), and 7 (22%) patients, respectively. EBV reactivation occurred early after ICU admission and was associated with longer ICU length-of-stay.
Conclusions: While in the ICU, critically-ill patients with Covid-19 are prone to develop reactivations due to various types of herpesviruses.
Keywords: Covid-19; Cytomegalovirus; Epstein -Barr virus.