J Clin Med . Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection

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J Clin Med


. 2021 Jan 17;10(2):E323.
doi: 10.3390/jcm10020323.
Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection


Laia C Belarte-Tornero ^{1 2} , Sandra Valdivielso-Mor? ¹ , Miren Vicente Elcano ³ , Eduard Sol?-Gonz?lez ¹ , Sonia Ru?z-Bustillo ^{1 4} , Alicia Calvo-Fern?ndez ^{1 2} , Isaac Subinara ⁵ , Paula Cabero ^{2 3} , Cristina Soler ² , H?ctor Cubero-Gallego ^{2 3} , Beatriz Vaquerizo ^{2 3 4} , N?ria Farr? ^{1 2 4}



Affiliations

• PMID: 33477268
• DOI: 10.3390/jcm10020323

Abstract

Background: The prevalence and prognostic value of chronic heart failure (CHF) in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has seldom been studied. The aim of this study was to analyze the prevalence and prognosis of CHF in this setting.
Methods: This single-center study included 829 consecutive patients with SARS-CoV-2 infection from February to April 2020. Patients with a previous history of CHF were matched 1:2 for age and sex. We analyze the prognostic value of pre-existing CHF. Prognostic implications of N terminal pro brain natriuretic peptide (NT-proBNP) levels on admission in the CHF cohort were explored.
Results: A total of 129 patients (43 CHF and 86 non-CHF) where finally included. All-cause mortality was higher in CHF patients compared to non-CHF patients (51.2% vs. 29.1%, p = 0.014). CHF was independently associated with 30-day mortality (hazard ratio (HR) 2.3, confidence interval (CI) 95%: 1.26-2.4). Patients with CHF and high-sensitivity troponin T < 14 ng/L showed excellent prognosis. An NT-proBNP level > 2598 pg/mL on admission was associated with higher 30-day mortality in patients with CHF.
Conclusions: All-cause mortality in CHF patients hospitalized due to SARS-CoV-2 infection was 51.2%. CHF was independently associated with all-cause mortality (HR 2.3, CI 95% 1.26-4.2). NT-proBNP levels could be used for stratification risk purposes to guide medical decisions if larger studies confirm this finding.

Keywords: COVID-19; NT-proBNP; SARS-CoV-2; biomarkers; coronavirus; heart failure; prognosis; troponin.