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Mycoses . Prevalence of opportunistic invasive aspergillosis in COVID-19 patients with severe pneumonia

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  • Mycoses . Prevalence of opportunistic invasive aspergillosis in COVID-19 patients with severe pneumonia


    Mycoses


    . 2020 Nov 20.
    doi: 10.1111/myc.13219. Online ahead of print.
    Prevalence of opportunistic invasive aspergillosis in COVID-19 patients with severe pneumonia


    Gonzalo Segrelles-Calvo 1 2 , Glauber R de S Araújo 3 , Estefanía Llopis-Pastor 1 , Javier Carrillo 1 4 , Marta Hernández-Hernández 1 , Laura Rey 1 , Nestor Rodríguez Melean 1 , Inés Escribano 1 2 , Esther Antón 1 , Celia Zamarro 1 , Mercedes García-Salmones 1 4 , Susana Frases 3



    Affiliations

    Abstract

    Background: As the global coronavirus pandemic (COVID-19) spreads across the world, new clinical challenges emerge in the hospital landscape. Among these challenges, the increased risk of coinfections is a major threat to the patients. Although still in a low number, due to the short time of the pandemic, studies that identified a significant number of hospitalized patients with COVID-19 who developed secondary fungal infections that led to serious complications and even death have been published.
    Objectives: In this scenario, we aim to determine the prevalence of invasive fungal infections (IFIs) and describe possible associated risk factors in patients admitted due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
    Patients/methods: We designed an open prospective observational study at the Rey Juan Carlos University Hospital (Mostoles, Spain), during the period from February 1 to April 30, 2020.
    Results: In this article, we reported seven patients with COVID-19-associated pulmonary aspergillosis (CAPA) who had a poor prognosis. Severely ill patients represent a high-risk group; therefore, we must actively investigate the possibility of aspergillosis in all of these patients. Larger cohort studies are needed to unravel the role of COVID-19 immunosuppressive therapy as a risk factor for aspergillosis.
    Conclusions: As the pandemic continues to spread across the world, further reports are needed to assess the frequency of emergent and highly resistant reemergent fungal infections during severe COVID-19. These coinfections are leading a significant number of patients with COVID-19 to death due to complications following the primary viral disease.

    Keywords: COVID-19; invasive aspergillosis; lung disease; opportunistic mycosis.

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