Am J Ophthalmol Case Rep . Bilateral macular hemorrhage in a patient with COVID-19

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Am J Ophthalmol Case Rep


. 2020 Dec;20:100958.
doi: 10.1016/j.ajoc.2020.100958. Epub 2020 Oct 9.
Bilateral macular hemorrhage in a patient with COVID-19


Rossella D'Aloisio ¹ , Vincenzo Nasillo ² , Matteo Gironi ³ , Rodolfo Mastropasqua ³



Affiliations

• PMID: 33073058
• PMCID: PMC7546668
• DOI: 10.1016/j.ajoc.2020.100958

Free PMC article

Abstract

Purpose: We report a case of a patient with a known hereditary spherocytosis who developed a bilateral macular hemorrhage in concurrence with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related respiratory syndrome.
Observations: Blood tests showed severe hemolytic anemia. Interestingly, the peripheral blood smear demonstrated a mixed pathogenesis of the hemolytic process (cold-agglutinin-mediated and non-immune-mediated due to spherocytosis).
Conclusions and importance: We argue that SARS-CoV-2 could have triggered the hemolytic process, which led to retinal hemorrhages due to endothelial anoxia from the low oxygen carrying capacity.

Keywords: Hereditary spherocytosis; Macular hemorrhage; SARS-CoV-2.