World J Clin Cases . Gastrointestinal insights during the COVID-19 epidemic

[tetano]

Kai Nie ¹ , Yuan-Yuan Yang ¹ , Min-Zi Deng ¹ , Xiao-Yan Wang ²



Affiliations

• PMID: 33024750
• PMCID: PMC7520780
• DOI: 10.12998/wjcc.v8.i18.3934

Abstract

Coronavirus disease-2019 (COVID-19) has so far caused hundreds of mortalities worldwide. Although respiratory symptoms are the main complication in COVID-19 patients, the disease is also associated with gastrointestinal problems, with diarrhea, nausea, and vomiting being primary COVID-19 symptoms. Thus, cancer and inflammatory bowel disease (IBD) management, stool viral tests, and virus exposure are major concerns in the context of COVID-19 epidemic. In patients with colorectal cancer and IBD, the colonic mucosa exhibits elevated angiotensin-converting enzyme 2 receptor levels, enhancing COVID-19 susceptibility. In some cases, positive viral stool tests may be the only indicator of infection at admission or after leaving quarantine. Without supplemental stool tests, the risk of undetected COVID-19 transmission is high. Moreover, viral exposure during the regular or emergency endoscopic examination should be avoided. We carefully discuss key gastrointestinal concerns with regard to COVID-19 and call for more attention to such problems.

Keywords: COVID-19; Colorectal cancer; Diarrhea; Inflammatory bowel disease; SARS-CoV-2; Stool tests.