Zhong Nan Da Xue Xue Bao Yi Xue Ban . Clinical characteristics of 71 patients with coronavirus disease 2019

[tetano]

Zhong Nan Da Xue Xue Bao Yi Xue Ban


. 2020 Jul 28;45(7):790-796.
doi: 10.11817/j.issn.1672-7347.2020.200187.
Clinical characteristics of 71 patients with coronavirus disease 2019


[Article in En, Chinese]

Miaomiao Xiao ¹ , Mingjie Hou ² , Xuhui Liu ² , Zhe Li ² , Qingxia Zhao ³



Affiliations

• PMID: 32879082
• DOI: 10.11817/j.issn.1672-7347.2020.200187

Abstract

in En , Chinese
Objectives: To analyze the clinical characteristics of 71 patients with coronavirus disease 2019 (COVID-19).
Methods: The general data, epidemiological data, laboratory tests, imaging examinations, and treatment of 71 patients with COVID-19 admitted to the Sixth People's Hospital of Zhengzhou from January 19, 2020 to March 3, 2020 were retrospectively analyzed.
Results: Of the 71 COVID-19 patients, the ages were 4-84 (41.29?15.21) years, 38 (53.5%) patients were male, 33 (46.5%) were female, and 52 (73.2%) were in 22 clusters. The main clinical manifestations were fever (78.9%), cough (64.8%), and sputum (38.0%). The fever was mainly low and moderate, with 49 patients (69.0%) at 37.3-39.0 ℃. Most of the leukocytes, neutrophils, and lymphocytes were normal, accounting for 47 (66.2%), 51 (71.8%), and 51 (71.8%) patients, respectively; a few of them were decreased, accounting for 21 (29.6%), 16 (22.5%), and 20 (28.2%) patients, respectively. There were 38 (53.5%) and 31 (43.7%) patients with the decreased CD4⁺ and CD8⁺ T cell counts, respectively. There were 41 (57.7%), 38 (53.5%), 32 (45.1%), 26(36.6%), 22 (31.0%), 20 (28.2%), 14 (19.7%), 14 (19.7%), and 9 (12.7%) patients with the increased levels of C-reactive protein, erythrocyte sedimentation rate, procalcitonin, fibrinogen,interleukin 6, lactate dehydrogenase,D-dimer,alanine aminotransferase, and aspartate aminotransferase, respectively. Of the 71 patients, the lung was involved in 60 (84.5%) patients, the double lung was involved in 47 (66.2%) patients, and the single lung was involved in 13 (18.3%) patients. The course of the disease was long, and the time from symptom onset to the second severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid negative transformation was (17.22?6.34) days.There were no significant differences in the incubation period (t=-0.453, P>0.05), the complicates (χ²=0.042, P>0.05), and the time from symptom onset to diagnosis (t=-1.330, P>0.05) in patients between the non-severe group and the severe group. The onset age, gender, SARS-CoV-2 nucleic acid negative time, lymphocyte count, D-dimer, C-reactive protein, total bilirubin, direct bilirubin, lactate dehydrogenase, calcium ion, CD4⁺ T cell count, CD8⁺ T cell count, calcitonin, procalcitonin, and troponin were significantly different between the severe group and the non-severe group (all P<0.05). Among the 71 patients, 4 (5.6%) patients were mild, 59 (83.1%) were normal, and 8 (11.3%) were severe or critical.
Conclusions: The aggregation phenomenon of COVID-19 is obvious. Fever and cough are the main clinical manifestations. White blood cells, neutrophils, and lymphocytes in the most patients in the early onset are normal. Most COVID-19 patients are light and ordinary type, with good prognosis.

Keywords: clinical characteristics; coronavirus disease 2019; cough; fever; pneumonia; severe acute respiratory syndrome coronavirus 2.