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Dermatol Ther
. 2020 Aug 10.
doi: 10.1111/dth.14170. Online ahead of print.
Maculopapular eruptions associated to COVID-19: a subanalysis of the COVID-Piel study
Alba Catal? 1 , Cristina Galv?n-Casas 2 , Gregorio Carretero-Hern?ndez 3 , Pedro Rodr?guez-Jim?nez 4 , Daniel Fern?ndez-Nieto 5 , Ana Rodr?guez-Villa 6 , ??igo Navarro-Fern?ndez 7 , Ricardo Ruiz-Villaverde 8 , Daniel Falkenhain-L?pez 9 , Mar Llamas-Velasco 4 , Luc?a Carnero-Gonzalez 10 , Juan Garc?a-Gavin 11 , Ofelia Baniandr?s 12 , Carlos Gonz?lez-Cruz 13 , V?ctor Morillas-Lahuerta 14 , Xavier Cubir? 15 , Ignasi Figueras 16 , Gerald Selda-Enriquez 5 , Xavier Fust?-Novell 17 , M?nica Roncero-Riesco 18 , Patr?cia Burgos-Blasco 5 , Jorge Roman? 19 , Joaquim Sol?-Ortigosa 20 , Ignacio Garc?a-Doval 21
Affiliations
- PMID: 32779280
- DOI: 10.1111/dth.14170
Abstract
Background: A previous study has defined the maculopapular subtype of manifestations of COVID-19.
Objectives: To describe and classify maculopapular eruptions associated with COVI-19.
Methods: We carried out a subanalysis of the maculopapular cases found in the previous cross-sectional study. Using a consensus, we defined 7 clinical patterns. We described patient demographics, the therapy received by the patient and the characteristics of each pattern.
Results: Consensus lead to the description of 7 major maculopapular patterns: Morbilliform (45.5%), Other maculopapular (20.0%), Purpuric (14.2%), Erythema multiforme-like (9.7%), Pytiriasis rosea-like (5.7%), Erythema elevatum diutinum-like (2.3%) and Perifollicular (2.3%). In most cases, maculopapular eruptions were coincident (61.9%) or subsequent (34.1%) to the onset of other COVID-19 manifestations. The most frequent were cough (76%), dyspnea (72%), fever (88%), and astenia (62%). Hospital admission due to pneumonia was frequent (61%). Drug intake was frequent (78%). Laboratory alterations associated with maculo-papular eruptions were high C-reactive protein, high D-Dimer, lymphopenia, high ferritin, high LDH, and high IL-6.
Limitations: The impossibility to define the cause-effect relationship of each pattern.
Conclusion: We provide a description of the cutaneous maculopapular manifestations associated with COVID-19. The cutaneous manifestations of COVID-19 are wide-ranging and can mimic other dermatoses. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; Coronavirus; Cutaneous Manifestations; Skin.