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J Crit Care. 2020 Apr 14;58:29-33. doi: 10.1016/j.jcrc.2020.04.004. [Epub ahead of print]
Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy.
Piva S1, Filippini M2, Turla F3, Cattaneo S4, Margola A5, De Fulviis S6, Nardiello I7, Beretta A8, Ferrari L9, Trotta R10, Erbici G11, Foc? E12, Castelli F13, Rasulo F14, Lanspa MJ15, Latronico N16.
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Abstract
PURPOSE:
An ongoing pandemic of COVID-19 that started in Hubei, China has resulted in massive strain on the healthcare infrastructure in Lombardy, Italy. The management of these patients is still evolving.
MATERIALS AND METHODS:
This is a single-center observational cohort study of critically ill patients infected with COVID-19. Bedside clinicians abstracted daily patient data on history, treatment, and short-term course. We describe management and a proposed severity scale for treatment used in this hospital.
RESULTS:
44 patients were enrolled; with incomplete information on 11. Of the 33 studied patients, 91% were male, median age 64; 88% were overweight or obese. 45% were hypertensive, 12% had been taking an ACE-inhibitor. Noninvasive ventilation was performed on 39% of patients for part or all or their ICU stay with no provider infection. Most patients received antibiotics for pneumonia. Patients also received lopinivir/ritonavir (82%), hydroxychloroquine (79%), and tocilizumab (12%) according to this treatment algorithm. Nine of 10 patients survived their ICU course and were transferred to the floor, with one dying in the ICU.
CONCLUSIONS:
ICU patients with COVID-19 frequently have hypertension. Many could be managed with noninvasive ventilation, despite the risk of aerosolization. The use of a severity scale augmented clinician management.
Copyright ? 2020 The Authors. Published by Elsevier Inc. All rights reserved.
KEYWORDS:
COVID-19; Novel coronavirus; SARS-CoV-2
PMID:32330817DOI:10.1016/j.jcrc.2020.04.004