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Clin Immunol. COVID-19 in a patient with long-term use of glucocorticoids: A study of a familial cluster

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  • Clin Immunol. COVID-19 in a patient with long-term use of glucocorticoids: A study of a familial cluster


    Clin Immunol. 2020 Apr 7:108413. doi: 10.1016/j.clim.2020.108413. [Epub ahead of print]
    COVID-19 in a patient with long-term use of glucocorticoids: A study of a familial cluster.


    Han Y1, Jiang M1, Xia D2, He L2, Lv X3, Liao X3, Meng J4.

    Author information




    Abstract

    Clusters of patients with novel coronavirus disease 2019 (COVID-19) have been successively reported globally. Studies show clear person-to-person transmission. The average incubation period is 2-14 days, and mostly 3-7 days. However, in some patients, this period may be longer. Here, we report a familial cluster of COVID-19 where a 47-year-old woman with long-term use of glucocorticoids did not develop any symptoms within the 14-day quarantine period but was confirmed with COVID-19 by tested positive of antibody on day 40 after she left Wuhan. Almost at the same time, her father and sister were diagnosed with COVID-19. The results suggest that the long-term use of glucocorticoids might cause atypical infections, a long incubation period, and extra transmission of COVID-19.
    Copyright © 2019. Published by Elsevier Inc.



    KEYWORDS:

    Atypical infection; COVID-19; Familial cluster; Immunocompromised; Incubation period; Shedding duration


    PMID:32276139PMCID:PMC7139268DOI:10.1016/j.clim.2020.108413

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