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Mycopathologia
. 2025 Jul 30;190(5):67.
doi: 10.1007/s11046-025-00971-5. Acute Respiratory Distress Syndrome Due to COVID-19-Associated Pulmonary Aspergillosis with Rare Extensive Tracheobronchial Pseudomembranous Involvement: A Case Report
Liu He 1 2 3 , Wei Wang 4 , Danyan Cai 2 , Xiaoshan Zhang 2 , Xinyuan Tan 5
Affiliations
COVID-19-associated pulmonary aspergillosis (CAPA) significantly exacerbates the clinical outcomes of COVID-19 patients, contributing to heightened mortality. Aspergillus tracheobronchitis, a manifestation of invasive pulmonary aspergillosis, specifically involves the tracheobronchial tree. According to the 2020 European Confederation of Medical Mycology/International Society for Human and Animal Mycology (ECMM/ISHAM) consensus criteria, airway biopsy via bronchoscopy is the definitive method for CAPA diagnosis, underscoring its critical role in the management of COVID-19 patients. This case report describes an elderly male patient with COVID-19 who presented with extensive pseudomembranous involvement of the tracheobronchial tree, identified through bronchoscopy. The pseudomembrane, spanning from the glottis to the bronchi and characterized by its yellow-white translucency, was removed. Subsequent pathological examination and next-generation sequencing confirmed an Aspergillus infection. Despite the initiation of antifungal therapy, the patient's condition deteriorated, leading to his death.
Keywords: Aspergillus tracheobronchitis; Acute respiratory distress syndrome; COVID-19-associated pulmonary aspergillosis; Case report; Extensive tracheobronchial pseudomembrane; Fungal infection; Pseudomembranous Aspergillus tracheobronchitis.
. 2025 Jul 30;190(5):67.
doi: 10.1007/s11046-025-00971-5. Acute Respiratory Distress Syndrome Due to COVID-19-Associated Pulmonary Aspergillosis with Rare Extensive Tracheobronchial Pseudomembranous Involvement: A Case Report
Liu He 1 2 3 , Wei Wang 4 , Danyan Cai 2 , Xiaoshan Zhang 2 , Xinyuan Tan 5
Affiliations
- PMID: 40742610
- DOI: 10.1007/s11046-025-00971-5
COVID-19-associated pulmonary aspergillosis (CAPA) significantly exacerbates the clinical outcomes of COVID-19 patients, contributing to heightened mortality. Aspergillus tracheobronchitis, a manifestation of invasive pulmonary aspergillosis, specifically involves the tracheobronchial tree. According to the 2020 European Confederation of Medical Mycology/International Society for Human and Animal Mycology (ECMM/ISHAM) consensus criteria, airway biopsy via bronchoscopy is the definitive method for CAPA diagnosis, underscoring its critical role in the management of COVID-19 patients. This case report describes an elderly male patient with COVID-19 who presented with extensive pseudomembranous involvement of the tracheobronchial tree, identified through bronchoscopy. The pseudomembrane, spanning from the glottis to the bronchi and characterized by its yellow-white translucency, was removed. Subsequent pathological examination and next-generation sequencing confirmed an Aspergillus infection. Despite the initiation of antifungal therapy, the patient's condition deteriorated, leading to his death.
Keywords: Aspergillus tracheobronchitis; Acute respiratory distress syndrome; COVID-19-associated pulmonary aspergillosis; Case report; Extensive tracheobronchial pseudomembrane; Fungal infection; Pseudomembranous Aspergillus tracheobronchitis.