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J Microbiol Immunol Infect
. 2025 Feb 5:S1684-1182(25)00035-0.
doi: 10.1016/j.jmii.2025.02.002. Online ahead of print. Life-threatening COVID-19 in a thymoma patient with anti-interferon-α autoantibodies
Yu-Shan Shih 1 , Wan-Ting Tsai 2 , Bei-Chia Guo 1 , Aristine Cheng 3 , Jann-Tay Wang 1
Affiliations
Neutralizing anti-interferon (IFN)-α autoantibodies can lead to immune dysregulation, potentially resulting in critical coronavirus disease 2019 (COVID-19). We report a case presenting with severe COVID-19 who was subsequently diagnosed to have thymoma and neutralizing anti-IFN-α autoantibodies.
Keywords: Anti-IFN-α autoantibodies; Critical COVID-19; Thymoma; Type 1 interferons; Viral infections.
. 2025 Feb 5:S1684-1182(25)00035-0.
doi: 10.1016/j.jmii.2025.02.002. Online ahead of print. Life-threatening COVID-19 in a thymoma patient with anti-interferon-α autoantibodies
Yu-Shan Shih 1 , Wan-Ting Tsai 2 , Bei-Chia Guo 1 , Aristine Cheng 3 , Jann-Tay Wang 1
Affiliations
- PMID: 39929767
- DOI: 10.1016/j.jmii.2025.02.002
Neutralizing anti-interferon (IFN)-α autoantibodies can lead to immune dysregulation, potentially resulting in critical coronavirus disease 2019 (COVID-19). We report a case presenting with severe COVID-19 who was subsequently diagnosed to have thymoma and neutralizing anti-IFN-α autoantibodies.
Keywords: Anti-IFN-α autoantibodies; Critical COVID-19; Thymoma; Type 1 interferons; Viral infections.