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Emerg Infect Dis
. 2024 Dec 10;31(1).
doi: 10.3201/eid3101.241236. Online ahead of print.
Replication Restriction of Influenza A(H5N1) Clade 2.3.4.4b Viruses by Human Immune Factor, 2023-2024
Jakob Ankerhold, Susanne Kessler, Martin Beer, Martin Schwemmle, Kevin Ciminski
We show that human myxovirus resistance protein 1 (MxA) suppresses replication of highly pathogenic avian influenza A(H5N1) viruses isolated from mammals in vitro and in MxA-transgenic mice. However, H5N1 can evade MxA restriction through replacement of individual viral polymerase complex components from a human-adapted MxA-resistant strain in vitro.
Keywords: H5N1 clade 2.3.4.4b; MxA; highly pathogenic avian influenza A(H5N1) viruses; influenza; risk assessment; virus; viruses; zoonoses; zoonotic transmission.
. 2024 Dec 10;31(1).
doi: 10.3201/eid3101.241236. Online ahead of print.
Replication Restriction of Influenza A(H5N1) Clade 2.3.4.4b Viruses by Human Immune Factor, 2023-2024
Jakob Ankerhold, Susanne Kessler, Martin Beer, Martin Schwemmle, Kevin Ciminski
- PMID: 39657579
- DOI: 10.3201/eid3101.241236
We show that human myxovirus resistance protein 1 (MxA) suppresses replication of highly pathogenic avian influenza A(H5N1) viruses isolated from mammals in vitro and in MxA-transgenic mice. However, H5N1 can evade MxA restriction through replacement of individual viral polymerase complex components from a human-adapted MxA-resistant strain in vitro.
Keywords: H5N1 clade 2.3.4.4b; MxA; highly pathogenic avian influenza A(H5N1) viruses; influenza; risk assessment; virus; viruses; zoonoses; zoonotic transmission.