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Sci Rep
. 2024 Aug 30;14(1):20148.
doi: 10.1038/s41598-024-68250-9. A large scale study of portable sweat test sensor for accurate, non-invasive and rapid COVID-19 screening based on volatile compound marker detection
Isaya Thaveesangsakulthai 1 , Kaywalee Chatdarong 2 , Naraporn Somboonna 3 4 5 , Nuttapon Pombubpa 3 4 , Tanapat Palaga 3 , Sureerat Makmuang 6 , Kanet Wongravee 6 , Voravee Hoven 1 7 , Pakpum Somboon 8 , Pattama Torvorapanit 9 10 , Thumnoon Nhujak 1 , Chadin Kulsing 11 12
Affiliations
This study established a novel infield sensing approach based on detection of the volatile compound markers in skin secretions. This was based on analysis of volatile compounds in axillary sweat samples collected from RT-PCR-proven Coronavirus disease 2019 (COVID-19) positive and negative populations using gas chromatography-mass spectrometry (GC-MS). The analysis proposed the possible markers of the monoaromatic compounds and ethyl hexyl acrylate. A portable photo ionization detector (PID) incorporated with the selective material towards the marker compounds was then developed with the pressurized injection approach. This provided the accuracy of 100% in the research phase (n = 125). The developed approach was then applied for screening of 2207 COVID-19 related cases covering the periods of the Alpha, Beta, Delta and Omicron variants of SARS-CoV-2 infection in Bangkok, Thailand. This offered the sensitivity, specificity and accuracy ranges of 92-99, 93-98 and 95-97%, respectively.
Keywords: COVID-19 screening; Disease diagnosis; Modified PID; Sweat sensor; VOCs.
. 2024 Aug 30;14(1):20148.
doi: 10.1038/s41598-024-68250-9. A large scale study of portable sweat test sensor for accurate, non-invasive and rapid COVID-19 screening based on volatile compound marker detection
Isaya Thaveesangsakulthai 1 , Kaywalee Chatdarong 2 , Naraporn Somboonna 3 4 5 , Nuttapon Pombubpa 3 4 , Tanapat Palaga 3 , Sureerat Makmuang 6 , Kanet Wongravee 6 , Voravee Hoven 1 7 , Pakpum Somboon 8 , Pattama Torvorapanit 9 10 , Thumnoon Nhujak 1 , Chadin Kulsing 11 12
Affiliations
- PMID: 39209886
- PMCID: PMC11362290
- DOI: 10.1038/s41598-024-68250-9
This study established a novel infield sensing approach based on detection of the volatile compound markers in skin secretions. This was based on analysis of volatile compounds in axillary sweat samples collected from RT-PCR-proven Coronavirus disease 2019 (COVID-19) positive and negative populations using gas chromatography-mass spectrometry (GC-MS). The analysis proposed the possible markers of the monoaromatic compounds and ethyl hexyl acrylate. A portable photo ionization detector (PID) incorporated with the selective material towards the marker compounds was then developed with the pressurized injection approach. This provided the accuracy of 100% in the research phase (n = 125). The developed approach was then applied for screening of 2207 COVID-19 related cases covering the periods of the Alpha, Beta, Delta and Omicron variants of SARS-CoV-2 infection in Bangkok, Thailand. This offered the sensitivity, specificity and accuracy ranges of 92-99, 93-98 and 95-97%, respectively.
Keywords: COVID-19 screening; Disease diagnosis; Modified PID; Sweat sensor; VOCs.