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J Med Virol
. 2022 Jul 13.
doi: 10.1002/jmv.27998. Online ahead of print.
Dynamics of nasopharyngeal tract phageome and association with disease severity and age of patients during three waves of COVID-19
Carlo Ferravante 1 , Berin S Arslan-Gatz 2 , Federica Dell'Annunziata 2 , Domenico Palumbo 1 , Jessica Lamberti 1 , Elena Alexandrova 1 , Domenico Di Rosa 1 , Oriana Strianese 3 , Alessandro Giordano 1 , Luigi Palo 1 , Giorgio Giurato 1 3 , Francesco A Salzano 4 , Massimiliano Galdiero 2 , Alessandro Weisz 1 3 5 , Gianluigi Franci 4 , Francesca Rizzo 1 3 , Veronica Folliero 2
Affiliations
- PMID: 35831579
- DOI: 10.1002/jmv.27998
Abstract
In December 2019, several patients were hospitalized and diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which subsequently led to a global pandemic. To date, there are no studies evaluating the relationship between the respiratory phageome and the SARS-CoV-2 infection. The current study investigated the phageome profiles in the nasopharyngeal swabs collected from 55 patients during the three different waves of COVID-19 in the Campania Region (Southern Italy). Data obtained from the taxonomic profiling show that phage families belonging to the order Caudovirales have a high abundance in the patient samples. Moreover, the severity of the COVID-19 infection seems to be correlated with the phage abundance. This article is protected by copyright. All rights reserved.
Keywords: SARS-CoV-2; bacteriophages; phageome; taxonomic analysis.