Respirol Case Rep . Post-coronavirus disease 2019 organizing pneumonia confirmed pathologically by video-assisted thoracoscopic surgery

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Respirol Case Rep


. 2021 Oct 28;9(12):e0871.
doi: 10.1002/rcr2.871. eCollection 2021 Dec.
Post-coronavirus disease 2019 organizing pneumonia confirmed pathologically by video-assisted thoracoscopic surgery


Keishi Sugino ¹ , Hirotaka Ono ¹ , Shuji Haraguchi ² , Seiji Igarashi ³ , Akira Hebisawa ⁴ , Eiyasu Tsuboi ¹



Affiliations

• PMID: 34745634
• PMCID: PMC8552080
• DOI: 10.1002/rcr2.871

Abstract

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has become a global pandemic. Many survivors of serious COVID-19 pneumonia have long-term residual pulmonary disease. However, there is little documentation of the histopathological characteristics of lung sequelae post-COVID-19 and effective treatments. We present two Japanese cases of lung sequelae post-COVID-19. The patients were histopathologically diagnosed with organizing pneumonia (OP) or OP with fibrosis and no diffuse alveolar damage on video-assisted thoracoscopic surgery. Case 1, who had been diagnosed with OP, was successfully treated with corticosteroid and other immunosuppressive agents over a 6-month period. Although case 2, who had been diagnosed with OP with fibrosis, had a partial and unsatisfactory response to immunosuppressive agents, the patient responded to antifibrotic treatment including nintedanib.

Keywords: coronavirus disease 2019; corticosteroid; organizing pneumonia; severe acute respiratory syndrome coronavirus 2; video‐assisted thoracoscopic surgery.