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BMC Infect Dis . The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients

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  • BMC Infect Dis . The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients


    BMC Infect Dis


    . 2021 Apr 20;21(1):371.
    doi: 10.1186/s12879-021-06057-z.
    The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients


    Liulin Wang 1 2 , Xiaobin Cheng 1 2 , Qiufen Dong 1 2 , Chenliang Zhou 3 , Yeming Wang 4 , Bin Song 5 , Weinan Li 2 6 , Min Wang 1 2 , Rui Qin 1 2 , Qi Long 1 2 , Juan Liu 1 2 , Jing Li 1 2 , Dan Li 1 2 , Gang Li 7 8 , Yuanming Ba 9 10



    Affiliations

    Abstract

    Background: The current coronavirus disease 2019 (COVID-19) is a public health emergency. In this study, we aimed to evaluate the risk factors for mortality in severe and critical COVID-19 patients.
    Methods: We performed a retrospective study of patients diagnosed with severe and critical COVID-19 from four hospitals in Wuhan, China, by evaluating the clinical characteristics and laboratory results, and using Cox proportional hazards model to assess the risk factors involved in disease progression.
    Results: In total, 446 patients with COVID-19 were enrolled. The study indicated a high mortality rate (20.2%) in severe and critical COVID-19 patients. At the time of admission, all patients required oxygen therapy, and 52 (12%) required invasive mechanical ventilation, of which 50 (96%) died. The univariate Cox proportional hazards model showed a white blood cell count of more than 10 × 109/L (HR 3.993,95%CI 2.469 to 6.459) that correlated with an increased mortality rate. The multivariable Cox proportional hazards model demonstrated that older age (HR 1.066, 95% CI 1.043 to 1.089) and higher white blood cell count (HR 1.135, 95% CI 1.080 to 1.192) were independent risk factors for determining COVID-19 associated mortality.
    Conclusions: COVID-19 is associated with a significant risk of morbidity and mortality in the population. Older age and higher white blood cell count were found to be independent risk factors for mortality.

    Keywords: COVID-19; Cox proportional hazards model; Laboratory tests; Risk factors.

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