Clin Chem Lab Med . IFCC interim guidelines on biochemical/hematological monitoring of COVID-19 patients

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Clin Chem Lab Med


. 2020 Oct 7;/j/cclm.ahead-of-print/cclm-2020-1414/cclm-2020-1414.xml.
doi: 10.1515/cclm-2020-1414. Online ahead of print.
IFCC interim guidelines on biochemical/hematological monitoring of COVID-19 patients


Simon Thompson ¹ , Mary Kathryn Bohn ^{2 3} , Nicasio Mancini ⁴ , Tze Ping Loh ⁵ , Cheng-Bin Wang ⁶ , Matthias Grimmler ⁷ , Kwok-Yung Yuen ⁸ , Robert Mueller ⁹ , David Koch ¹⁰ , Sunil Sethi ⁵ , William D Rawlinson ¹¹ , Massimo Clementi ⁴ , Rajiv Erasmus ¹² , Marc Leportier ¹³ , Gye Cheol Kwon ¹⁴ , Mar?a Elizabeth Menezes ¹⁵ , Maria-Magdalena Patru ¹⁶ , Maurizio Gramegna ¹⁷ , Krishna Singh ¹⁸ , Osama Najjar ¹⁹ , Maurizio Ferrari ⁴ , Giuseppe Lippi ²⁰ , Khosrow Adeli ^{2 3} , Andrea Horvath ^{1 1 21}



Affiliations

• PMID: 33027044
• DOI: 10.1515/cclm-2020-1414

Abstract

Routine biochemical and hematological tests have been reported to be useful in the stratification and prognostication of pediatric and adult patients with diagnosed coronavirus disease (COVID-19), correlating with poor outcomes such as the need for mechanical ventilation or intensive care, progression to multisystem organ failure, and/or death. While these tests are already well established in most clinical laboratories, there is still debate regarding their clinical value in the management of COVID-19, particularly in pediatrics, as well as the value of composite clinical risk scores in COVID-19 prognostication. This document by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Task Force on COVID-19 provides interim guidance on: (A) clinical indications for testing, (B) recommendations for test selection and interpretation, (C) considerations in test interpretation, and (D) current limitations of biochemical/hematological monitoring of COVID-19 patients. These evidence-based recommendations will provide practical guidance to clinical laboratories worldwide, underscoring the contribution of biochemical and hematological testing to our collective pandemic response.

Keywords: COVID-19; SARS-CoV-2; biochemistry; hematology.