Emerg Infect Dis . Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results - FluTrackers News and Information

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Emerg Infect Dis . Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results

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tetano

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Emerg Infect Dis . Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results

July 30, 2020, 05:02 AM

Emerg Infect Dis

. 2020 Jul 29;26(10).
doi: 10.3201/eid2610.202632. Online ahead of print.
Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results

Marie K Das, Anu Chaudhary, Andrew Bryan, Mark H Wener, Susan L Fink, Chihiro Morishima
PMID: 32723430

DOI: 10.3201/eid2610.202632

Abstract

Many serologic tests are now available for measuring severe acute respiratory syndrome coronavirus 2 antibodies to evaluate potential protective immunity and for seroprevalence studies. We describe an approach to standardizing positivity thresholds and quantitative values for different assays that uses z-scores to enable rapid and efficient comparison of serologic test performance.

Keywords: COVID19; IgG; SARS-CoV-2; antibody; coronavirus; coronavirus disease; performance; qualitative results; quantitative results; respiratory infections; screening; serologic analysis; severe acute respiratory syndrome coronavirus 2; standardization; viruses; z-scores; zoonoses.

Tags: None

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