Thromb Res. The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: A retrospective study in Suzhou China

[tetano]

Thromb Res. 2020 May 6;192:3-8. doi: 10.1016/j.thromres.2020.05.006. [Epub ahead of print]
The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: A retrospective study in Suzhou China.


Fu J¹, Kong J², Wang W³, Wu M⁴, Yao L⁴, Wang Z⁵, Jin J², Wu D⁶, Yu X⁷.

Author information




Abstract

OBJECTIVE:

To investigate the clinical features of COVID-19 cases in Suzhou China. Biomarkers were screened out of hematological parameters for risk stratification.
METHOD:

Confirmed COVID-19 adult patients in Suzhou were included. The patient data was collected, and the results of laboratory examinations were compared between the mild/moderate and severe COVID-19 groups. A ROC was calculated to compare the diagnostic performance of candidate indexes, and dynamic levels of hematological indexes were compared between the two groups.
RESULT:

75 patients were enrolled, with a mean age of 46.6 ? 14 years, and 45 patients were male. All patients were classified into two groups: the mild/moderate group and the severe group. WBC, neutrophil to lymphocyte ratio (NLR), D-dimer, and fibrinogen levels of the severe group were significantly higher (P < 0.05) than the mild/moderate, and the lymphocyte was lower. The ROC test showed that the hematological parameters had a larger AUC than that of inflammatory factors. There was a significant difference in lymphocyte and fibrinogen levels between the two groups on day 1 (P < 0.05). However, NLR of the severe group was higher than the mild/moderate on days 1, 4 and 14 (P < 0.01), and so was D-dimer on days 1, 7 and 14 (P < 0.05).
CONCLUSION:

The common COVID-19 abnormal hematological indexes on admission included hyperfibrinogenemia, lymphopenia, the elevation of D-dimer, and leukopenia, which were significantly different between the mild/moderate and severe COVID-19 groups. Furthermore, the dynamic change of NLR and D-dimer level can distinguish severe COVID-19 cases from the mild/moderate.
Copyright ? 2020. Published by Elsevier Ltd.



KEYWORDS:

Coronavirus disease 2019; D-dimer; Neutrophil to lymphocyte ratio


PMID:32407937DOI:10.1016/j.thromres.2020.05.006