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Nature
. 2023 Dec 13.
doi: 10.1038/s41586-023-06803-0. Online ahead of print. Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes
Samuel Philip Nobs # 1 , Aleksandra A Kolodziejczyk # 1 2 , Lital Adler 3 , Nir Horesh 1 4 5 , Christine Botscharnikow 1 , Ella Herzog 1 , Gayatree Mohapatra 1 , Sophia Hejndorf 1 , Ryan-James Hodgetts 1 , Igor Spivak 1 , Lena Schorr 6 7 , Leviel Fluhr 1 , Denise Kviatcovsky 1 , Anish Zacharia 8 , Suzanne Njuki 8 , Dinorah Barasch 8 , Noa Stettner 9 , Mally Dori-Bachash 1 , Alon Harmelin 9 , Alexander Brandis 10 , Tevie Mehlman 10 , Ayelet Erez 3 , Yiming He 1 , Sara Ferrini 1 , Jens Puschhof 6 , Hagit Shapiro 1 , Manfred Kopf 11 , Arieh Moussaieff 8 , Suhaib K Abdeen 12 , Eran Elinav 13 14
Affiliations
People with diabetes feature a life-risking susceptibility to respiratory viral infection, including influenza and SARS-CoV-2 (ref. 1), whose mechanism remains unknown. In acquired and genetic mouse models of diabetes, induced with an acute pulmonary viral infection, we demonstrate that hyperglycaemia leads to impaired costimulatory molecule expression, antigen transport and T cell priming in distinct lung dendritic cell (DC) subsets, driving a defective antiviral adaptive immune response, delayed viral clearance and enhanced mortality. Mechanistically, hyperglycaemia induces an altered metabolic DC circuitry characterized by increased glucose-to-acetyl-CoA shunting and downstream histone acetylation, leading to global chromatin alterations. These, in turn, drive impaired expression of key DC effectors including central antigen presentation-related genes. Either glucose-lowering treatment or pharmacological modulation of histone acetylation rescues DC function and antiviral immunity. Collectively, we highlight a hyperglycaemia-driven metabolic-immune axis orchestrating DC dysfunction during pulmonary viral infection and identify metabolic checkpoints that may be therapeutically exploited in mitigating exacerbated disease in infected diabetics.
. 2023 Dec 13.
doi: 10.1038/s41586-023-06803-0. Online ahead of print. Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes
Samuel Philip Nobs # 1 , Aleksandra A Kolodziejczyk # 1 2 , Lital Adler 3 , Nir Horesh 1 4 5 , Christine Botscharnikow 1 , Ella Herzog 1 , Gayatree Mohapatra 1 , Sophia Hejndorf 1 , Ryan-James Hodgetts 1 , Igor Spivak 1 , Lena Schorr 6 7 , Leviel Fluhr 1 , Denise Kviatcovsky 1 , Anish Zacharia 8 , Suzanne Njuki 8 , Dinorah Barasch 8 , Noa Stettner 9 , Mally Dori-Bachash 1 , Alon Harmelin 9 , Alexander Brandis 10 , Tevie Mehlman 10 , Ayelet Erez 3 , Yiming He 1 , Sara Ferrini 1 , Jens Puschhof 6 , Hagit Shapiro 1 , Manfred Kopf 11 , Arieh Moussaieff 8 , Suhaib K Abdeen 12 , Eran Elinav 13 14
Affiliations
- PMID: 38093014
- DOI: 10.1038/s41586-023-06803-0
People with diabetes feature a life-risking susceptibility to respiratory viral infection, including influenza and SARS-CoV-2 (ref. 1), whose mechanism remains unknown. In acquired and genetic mouse models of diabetes, induced with an acute pulmonary viral infection, we demonstrate that hyperglycaemia leads to impaired costimulatory molecule expression, antigen transport and T cell priming in distinct lung dendritic cell (DC) subsets, driving a defective antiviral adaptive immune response, delayed viral clearance and enhanced mortality. Mechanistically, hyperglycaemia induces an altered metabolic DC circuitry characterized by increased glucose-to-acetyl-CoA shunting and downstream histone acetylation, leading to global chromatin alterations. These, in turn, drive impaired expression of key DC effectors including central antigen presentation-related genes. Either glucose-lowering treatment or pharmacological modulation of histone acetylation rescues DC function and antiviral immunity. Collectively, we highlight a hyperglycaemia-driven metabolic-immune axis orchestrating DC dysfunction during pulmonary viral infection and identify metabolic checkpoints that may be therapeutically exploited in mitigating exacerbated disease in infected diabetics.