Tweet
Front Immunol. 2019 Jul 18;10:1677. doi: 10.3389/fimmu.2019.01677. eCollection 2019.
Protective Antibodies Against Influenza Proteins.
Padilla-Quirarte HO1,2, Lopez-Guerrero DV3, Gutierrez-Xicotencatl L4, Esquivel-Guadarrama F1.
Author information
Abstract
The influenza A virus infection continues to be a threat to the human population. The seasonal variation of the virus and the likelihood of periodical pandemics caused by completely new virus strains make it difficult to produce vaccines that efficiently protect against this infection. Antibodies (Abs) are very important in preventing the infection and in blocking virus propagation once the infection has taken place. However, the precise protection mechanism provided by these Abs still needs to be established. Furthermore, most research has focused on Abs directed to the globular head domain of hemagglutinin (HA). However, other domains of HA (like the stem) and other proteins are also able to elicit protective Ab responses. In this article, we review the current knowledge about the role of both neutralizing and non-neutralizing anti-influenza proteins Abs that play a protective role during infection or vaccination.
KEYWORDS:
influenza A virus; influenza proteins; neutralizing antibodies; non-neutralizing antibidies; protective antibodies
PMID: 31379866 PMCID: PMC6657620 DOI: 10.3389/fimmu.2019.01677
Protective Antibodies Against Influenza Proteins.
Padilla-Quirarte HO1,2, Lopez-Guerrero DV3, Gutierrez-Xicotencatl L4, Esquivel-Guadarrama F1.
Author information
Abstract
The influenza A virus infection continues to be a threat to the human population. The seasonal variation of the virus and the likelihood of periodical pandemics caused by completely new virus strains make it difficult to produce vaccines that efficiently protect against this infection. Antibodies (Abs) are very important in preventing the infection and in blocking virus propagation once the infection has taken place. However, the precise protection mechanism provided by these Abs still needs to be established. Furthermore, most research has focused on Abs directed to the globular head domain of hemagglutinin (HA). However, other domains of HA (like the stem) and other proteins are also able to elicit protective Ab responses. In this article, we review the current knowledge about the role of both neutralizing and non-neutralizing anti-influenza proteins Abs that play a protective role during infection or vaccination.
KEYWORDS:
influenza A virus; influenza proteins; neutralizing antibodies; non-neutralizing antibidies; protective antibodies
PMID: 31379866 PMCID: PMC6657620 DOI: 10.3389/fimmu.2019.01677