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J Virol. 2009 Apr 15. [Epub ahead of print]
RuvB-like 2 protein is a suppressor of influenza A virus polymerases.
Kakugawa S, Shimojima M, Neumann G, Goto H, Kawaoka Y. - Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokaneda, Minato-ku, Tokyo 108-8639, Japan; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA;
Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Saitama 332-0012, Japan; International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
In pro- and eukaryotic cells, RuvB-like 2 protein (RBL2) resolves Holliday junction recombination intermediates. Here, we identified RBL2 as a suppressor of influenza A virus replication.
hRBL2 appears to interfere with the oligomerization of the viral nucleoprotein, a critical step in the assembly of viral replication complexes.
PMID: 19369355 [PubMed - as supplied by publishe
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RuvB-like 2 protein is a suppressor of influenza A virus polymerases.
Kakugawa S, Shimojima M, Neumann G, Goto H, Kawaoka Y. - Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokaneda, Minato-ku, Tokyo 108-8639, Japan; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA;
Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Saitama 332-0012, Japan; International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
In pro- and eukaryotic cells, RuvB-like 2 protein (RBL2) resolves Holliday junction recombination intermediates. Here, we identified RBL2 as a suppressor of influenza A virus replication.
hRBL2 appears to interfere with the oligomerization of the viral nucleoprotein, a critical step in the assembly of viral replication complexes.
PMID: 19369355 [PubMed - as supplied by publishe
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