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Viruses. 2012 Sep;4(9):1438-76. doi: 10.3390/v4091438. Epub 2012 Sep 3.
Evasion of influenza a viruses from innate and adaptive immune responses.
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF.
Source
Department of Virology, ErasmusMC, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands; Email: c.vandesandt@erasmusmc.nl (C.E.S.); j.kreijtz@erasmusmc.nl (J.H.C.M.K.).
Abstract
The influenza A virus is one of the leading causes of respiratory tract infections in humans. Upon infection with an influenza A virus, both innate and adaptive immune responses are induced. Here we discuss various strategies used by influenza A viruses to evade innate immune responses and recognition by components of the humoral and cellular immune response, which consequently may result in reduced clearing of the virus and virus-infected cells. Finally, we discuss how the current knowledge about immune evasion can be used to improve influenza A vaccination strategies.
PMID:
23170167
[PubMed - in process]
PMCID:
PMC3499814
Evasion of influenza a viruses from innate and adaptive immune responses.
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF.
Source
Department of Virology, ErasmusMC, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands; Email: c.vandesandt@erasmusmc.nl (C.E.S.); j.kreijtz@erasmusmc.nl (J.H.C.M.K.).
Abstract
The influenza A virus is one of the leading causes of respiratory tract infections in humans. Upon infection with an influenza A virus, both innate and adaptive immune responses are induced. Here we discuss various strategies used by influenza A viruses to evade innate immune responses and recognition by components of the humoral and cellular immune response, which consequently may result in reduced clearing of the virus and virus-infected cells. Finally, we discuss how the current knowledge about immune evasion can be used to improve influenza A vaccination strategies.
PMID:
23170167
[PubMed - in process]
PMCID:
PMC3499814
