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J Virol. 2011 Sep 14. [Epub ahead of print]
Characterization of the human CD8+ T cell response following infection with 2009 pandemic influenza H1N1 virus.
Hillaire ML, van Trierum SE, Bodewes R, van Baalen CA, van Binnendijk RS, Koopmans MP, Fouchier RA, Osterhaus AD, Rimmelzwaan GF.
Source
Department of Virology, Erasmus Medical Center, Rotterdam, the Netherlands.
Abstract
The 2009 H1N1 influenza pandemic provided an opportunity to study human virus-specific T cell responses after infection with a novel influenza virus against which limited humoral immunity existed in the population. Here we describe the magnitude, kinetics and the nature of the virus-specific T cell response using intracellular IFN- γ staining and fluorochrome-labelled MHC class I/peptide complexes. We demonstrate that virus-infected patients develop recall T cells responses that peak within one week post infection and that contract rapidly. Especially, effector cell frequencies declined rapidly post infection in favour of relatively larger proportions of central memory cells.
PMID:
21917970
[PubMed - as supplied by publisher]
Characterization of the human CD8+ T cell response following infection with 2009 pandemic influenza H1N1 virus.
Hillaire ML, van Trierum SE, Bodewes R, van Baalen CA, van Binnendijk RS, Koopmans MP, Fouchier RA, Osterhaus AD, Rimmelzwaan GF.
Source
Department of Virology, Erasmus Medical Center, Rotterdam, the Netherlands.
Abstract
The 2009 H1N1 influenza pandemic provided an opportunity to study human virus-specific T cell responses after infection with a novel influenza virus against which limited humoral immunity existed in the population. Here we describe the magnitude, kinetics and the nature of the virus-specific T cell response using intracellular IFN- γ staining and fluorochrome-labelled MHC class I/peptide complexes. We demonstrate that virus-infected patients develop recall T cells responses that peak within one week post infection and that contract rapidly. Especially, effector cell frequencies declined rapidly post infection in favour of relatively larger proportions of central memory cells.
PMID:
21917970
[PubMed - as supplied by publisher]
